dc.contributor
[Blot S, Blot K] Department of Internal Medicine and Pediatrics, Ghent University, Campus UZ Gent, Ghent, Belgium. [Antonelli M] Department of Anesthesiology, Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. Università Cattolica del Sacro Cuore, Rome, Italy. [Arvaniti K] Intensive Care Unit, Papageorgiou University Affiliated Hospital, Thessaloníki, Greece. [Creagh-Brown, B] Surrey Perioperative Anaesthetic Critical Care Collaborative Research Group (SPACeR), Royal Surrey County Hospital, Guildford, UK. Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK. [de Lange D] Department of Intensive Care Medicine, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands. [Rello J] Centro de investigación en red de enfermedades respiratorias (CIBERES), Madrid, Spain. Recerca clínica/Innovació en la pneumònia i sèpsia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Blot, Stijn
dc.contributor.author
Blot, Koen
dc.contributor.author
Creagh-Brown, Ben
dc.contributor.author
Rello Condomines, Jordi
dc.contributor.author
Antonelli, Massimo
dc.contributor.author
Arvaniti, Kostoula
dc.contributor.author
de Lange, Dylan
dc.date.accessioned
2025-10-24T08:49:38Z
dc.date.available
2025-10-24T08:49:38Z
dc.date.issued
2020-09-02T08:16:58Z
dc.date.issued
2020-09-02T08:16:58Z
dc.date.issued
2019-10-29
dc.identifier
Blot S, Antonelli M, Arvaniti K, Blot K, Creagh-Brown B, de Lange D, et al. Epidemiology of intra-abdominal infection and sepsis in critically ill patients: “AbSeS”, a multinational observational cohort study and ESICM Trials Group Project. Intensive Care Med. 2019 Oct 29;45(12):1703–17.
dc.identifier
https://hdl.handle.net/11351/5205
dc.identifier
10.1007/s00134-019-05819-3
dc.identifier
000493268200001
dc.identifier.uri
http://hdl.handle.net/11351/5205
dc.description.abstract
Intra-abdominal infection; Peritonitis; Sepsis
dc.description.abstract
Infección intraabdominal; Peritonitis; Septicemia
dc.description.abstract
Infecció intraabdominal; Peritonitis; Sèpsia
dc.description.abstract
Purpose: To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock). Methods: We performed a multicenter (n = 309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis. Results: The cohort included 2621 patients. Setting of infection acquisition was community-acquired in 31.6%, early onset hospital-acquired in 25%, and late-onset hospital-acquired in 43.4% of patients. Overall prevalence of antimicrobial resistance was 26.3% and difficult-to-treat resistant Gram-negative bacteria 4.3%, with great variation according to geographic region. No difference in prevalence of antimicrobial resistance was observed according to setting of
infection acquisition. Overall mortality was 29.1%. Independent risk factors for mortality included late-onset hospitalacquired infection, diffuse peritonitis, sepsis, septic shock, older age, malnutrition, liver failure, congestive heart failure, antimicrobial resistance (either methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing Gram-negative bacteria, or carbapenem-resistant Gram-negative bacteria) and source control failure evidenced by either the need for surgical revision or persistent inflammation. Conclusion: This multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. Antimicrobial resistance is equally common in community-acquired as in hospital-acquired infection.
dc.description.abstract
The study was supported by a Pfizer investigator-initiated research grant
dc.format
application/pdf
dc.format
application/pdf
dc.publisher
Springer Nature
dc.relation
Intensive Care Medicine;45(12)
dc.relation
https://link.springer.com/article/10.1007%2Fs00134-019-05819-3
dc.rights
Attribution-NonCommercial 4.0 International
dc.rights
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Raonament basat en casos
dc.subject
Tracte gastrointestinal - Malalties
dc.subject
DISEASES::Infections::Intraabdominal Infections
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Cohort Studies
dc.subject
DISEASES::Infections::Sepsis
dc.subject
ENFERMEDADES::infecciones bacterianas y micosis::infección::infecciones intraabdominales
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de cohortes
dc.subject
ENFERMEDADES::infecciones bacterianas y micosis::infección::sepsis
dc.title
Epidemiology of intra-abdominal infection and sepsis in critically ill patients: “AbSeS”, a multinational observational cohort study and ESICM Trials Group Project
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
