dc.contributor
[Hernández C, Bogdanov P, Sampedro J, Solà-Adell C, García-Ramírez M, Simó R] Grup de Diabetis i Metabolisme, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [Gómez-Guerrero C] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Renal, Vascular and Diabetes Research Lab, Instituto de Investigacion Sanitaria-Fundación Jimenez Diaz (IIS-FJD), Madrid, Spain. Autonoma University of Madrid (UAM), Madrid, Spain. [Espejo, C] Recerca en Neuroimmunologia clínica, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain.
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Hernández Pascual, Cristina
dc.contributor.author
Bogdanov Baruj, Patricia
dc.contributor.author
Gómez-Guerrero, Carmen
dc.contributor.author
Sampedro Vida, Joel
dc.contributor.author
Solà Adell, Cristina
dc.contributor.author
Espejo Ruiz, Carmen
dc.contributor.author
García Ramírez, Marta
dc.contributor.author
Simó Canonge, Rafael
dc.date.accessioned
2025-10-24T08:53:39Z
dc.date.available
2025-10-24T08:53:39Z
dc.date.issued
2020-02-04T13:37:12Z
dc.date.issued
2020-02-04T13:37:12Z
dc.date.issued
2019-07-24
dc.identifier
Hernández C, Bogdanov P, Gómez-Guerrero C, Sampedro J, Solà-Adell C, Espejo C, et al. SOCS1-Derived Peptide Administered by Eye Drops Prevents Retinal Neuroinflammation and Vascular Leakage in Experimental Diabetes. Int J Mol Sci. 2019 Jul 24;20(15):3615.
dc.identifier
https://hdl.handle.net/11351/4586
dc.identifier
10.3390/ijms20153615
dc.identifier
000482383000008
dc.identifier.uri
http://hdl.handle.net/11351/4586
dc.description.abstract
Diabetic retinopathy; Neuroinflammation; Suppressors of cytokine signaling
dc.description.abstract
Retinopatía diabética; Neuroinflamación; Supresores de señalizadores de citoquinas
dc.description.abstract
Retinopatia diabètica; Neuroinflamació; Supressors de senyalitzadors de citoquines
dc.description.abstract
Current treatments for diabetic retinopathy (DR) target late stages when vision has already been significantly affected. Accumulating evidence suggests that neuroinflammation plays a major role in the pathogenesis of DR, resulting in the disruption of the blood-retinal barrier. Suppressors of cytokine signaling (SOCS) are cytokine-inducible proteins that function as a negative feedback loop regulating cytokine responses. On this basis, the aim of the present study was to evaluate the effect of a SOCS1-derived peptide administered by eye drops (2 weeks) on retinal neuroinflammation and early microvascular abnormalities in a db/db mouse model. In brief, we found that SOCS1-derived peptide significantly reduced glial activation and neural apoptosis induced by diabetes, as well as retinal levels of proinflammatory cytokines. Moreover, a significant improvement of electroretinogram parameters was observed, thus revealing a clear impact of the histological findings on global retinal function. Finally, SOCS1-derived peptide prevented the disruption of the blood-retinal barrier. Overall, our results suggest that topical administration of SOCS1-derived peptide is effective in preventing retinal neuroinflammation and early microvascular impairment. These findings could open up a new strategy for the treatment of early stages of DR.
dc.description.abstract
This study was supported by grants from the Ministerio de Economia y Competitividad (PI16/00541, SAF2015-63696-R, PI14/00386, PI17/01495 and DTS-2017/00203). Cristina Sola-Adell is a recipient of a Predoctoral Research Grant from MINECO (BES-2013-064944). Joel Sampedro is a recipient of a Predoctoral Research Grant from AGAUR.
dc.format
application/pdf
dc.relation
International Journal of Molecular Sciences;20(15)
dc.relation
https://www.mdpi.com/1422-0067/20/15/3615
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Retinopatia diabètica
dc.subject
Retina - Vasos sanguinis
dc.subject
DISEASES::Endocrine System Diseases::Diabetes Mellitus::Diabetes Complications::Diabetic Angiopathies::Diabetic Retinopathy
dc.subject
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Amino Acids, Peptides, and Proteins::Proteins::Amino Acids, Peptides, and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::Adaptor Proteins, Signal Transducing::Suppressor of Cytokine Signaling Proteins
dc.subject
ANATOMY::Cardiovascular System::Blood-Retinal Barrier
dc.subject
ENFERMEDADES::enfermedades del sistema endocrino::diabetes mellitus::complicaciones de la diabetes::angiopatías diabéticas::retinopatía diabética
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intracelular::proteínas adaptadoras transductoras de señales::proteínas supresoras de la señalización de citocinas
dc.subject
ANATOMÍA::sistema cardiovascular::barrera hematorretinal
dc.title
SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
