dc.contributor
Institut Català de la Salut
dc.contributor
[Makhani N] Department of Pediatrics, Yale University School of Medicine, USA. Department of Neurology, Yale University School of Medicine, USA. [Lebrun C] CRCSEP Nice Hopital Pasteur, Nice, France. [Siva A] University of Istanbul, Istanbul, Turkey. Cerrahpasa School of Medicine, Istanbul, Turkey. [Narula S] Children's Hospital of Philadelphia, Philadelphia, USA. University of Pennsylvania, Philadelphia, USA. [Wassmer E] Department of Neurology, The Birmingham Children's Hospital NHS Trust, Birmingham, UK. [Brassat D] Centre Hospitalo Universitaire Purpan, Toulouse, France. [Tintoré M] Centre d'Esclerosi Múltiple de Catalunya, Barcelona, Spain.
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Makhani, Naila
dc.contributor.author
Lebrun, Christine
dc.contributor.author
Siva, Aksel
dc.contributor.author
Narula, Sona
dc.contributor.author
Wassmer, Evangeline
dc.contributor.author
Brassat, David
dc.contributor.author
Tintore Subirana, Mar
dc.date.accessioned
2025-10-25T08:58:47Z
dc.date.available
2025-10-25T08:58:47Z
dc.date.issued
2019-05-08T10:07:31Z
dc.date.issued
2019-05-08T10:07:31Z
dc.date.issued
2019-03-20
dc.identifier
Makhani N, Lebrun C, Siva A, Narula S, Wassmer E, Brassat D, et al. Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome. Mult Scler J - Exp Transl Clin. 2019; 5(1):205521731983666.
dc.identifier
https://hdl.handle.net/11351/4063
dc.identifier
10.1177/2055217319836664
dc.identifier.uri
http://hdl.handle.net/11351/4063
dc.description.abstract
Radiologically isolated syndrome; Children; Multiple sclerosis
dc.description.abstract
Síndrome radiològicament aïllat; Nens; Esclerosi múltiple
dc.description.abstract
Síndrome radiológicamente aislado; Niños; Esclerosis múltiple
dc.description.abstract
BACKGROUND:
Steps towards the development of diagnostic criteria are needed for children with the radiologically isolated syndrome to identify children at risk of clinical demyelination.
OBJECTIVES:
To evaluate the 2005 and 2016 MAGNIMS magnetic resonance imaging criteria for dissemination in space for multiple sclerosis, both alone and with oligoclonal bands in cerebrospinal fluid added, as predictors of a first clinical event consistent with central nervous system demyelination in children with radiologically isolated syndrome.
METHODS:
We analysed an international historical cohort of 61 children with radiologically isolated syndrome (≤18 years), defined using the 2010 magnetic resonance imaging dissemination in space criteria (Ped-RIS) who were followed longitudinally (mean 4.2 ± 4.7 years). All index scans also met the 2017 magnetic resonance imaging dissemination in space criteria.
RESULTS:
Diagnostic indices (95% confidence intervals) for the 2005 dissemination in space criteria, with and without oligoclonal bands, were: sensitivity 66.7% (38.4-88.2%) versus 72.7% (49.8-89.3%); specificity 83.3% (58.6-96.4%) versus 53.9% (37.2-69.9%). For the 2016 MAGNIMS dissemination in space criteria diagnostic indices were: sensitivity 76.5% (50.1-93.2%) versus 100% (84.6-100%); specificity 72.7% (49.8-89.3%) versus 25.6% (13.0-42.1%).
CONCLUSIONS:
Oligoclonal bands increased the specificity of magnetic resonance imaging criteria in children with Ped-RIS. Clinicians should consider testing cerebrospinal fluid to improve diagnostic certainty. There is rationale to include cerebrospinal fluid analysis for biomarkers including oligoclonal bands in planned prospective studies to develop optimal diagnostic criteria for radiologically isolated syndrome in children
dc.format
application/pdf
dc.publisher
SAGE Publications
dc.relation
Multiple Sclerosis Journal - Experimental, Translational and Clinical;5(1)
dc.relation
https://journals.sagepub.com/doi/10.1177/2055217319836664
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Esclerosi múltiple - Imatgeria
dc.subject
Immunoglobulines
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DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
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Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
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CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Oligoclonal Bands
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NAMED GROUPS::Persons::Age Groups::Child
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NAMED GROUPS::Persons::Age Groups::Adolescent
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ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple
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Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::bandas oligoclonales
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DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::niño
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DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::adolescente
dc.title
Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
