dc.contributor
[Garcia-Gil M] Unitat de Suport a la Recerca Girona, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Girona, Spain. Grup d’Investigació Translab, Departament de Ciències Mèdiques, Facultat de Medicina, Universitat de Girona, Girona, Spain. [Reyes C] Grup d’Investigació GREMPAL, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain. CIBERFes, Universitat Autònoma de Barcelona and Instituto de Salud Carlos III, Barcelona, Spain. [Ramos R] Unitat de Suport a la Recerca-Girona, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Girona, Spain. Centres d’Atenció Primària, Institut Català de la Salut, Girona, Spain. [Sanchez-Santos MT] Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom. Arthritis Research UK Sports Exercise and Osteoarthritis Centre of Excellence, University of Oxford, Oxford, United Kingdom. [Prieto-Alhambra D] Grup d’Investigació GREMPAL, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain. CIBERFes, Universitat Autònoma de Barcelona and Instituto de Salud Carlos III, Barcelona, Spain. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom. Arthritis Research UK Sports Exercise and Osteoarthritis Centre of Excellence, University of Oxford, Oxford, United Kingdom. [Spector TD, Hart DJ] Department of Twin Research & Genetic Epidemiology, King’s College London, Oxford, United Kingdom. [Arden NK] Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom. Arthritis Research UK Sports Exercise and Osteoarthritis Centre of Excellence, University of Oxford, Oxford, United Kingdom. MRC Lifecourse Epidemiology Unit, University of Southampton, Oxford, United Kingdom
dc.contributor
IDIAP Jordi Gol
dc.contributor.author
García-Gil, Maria
dc.contributor.author
Reyes, Catalina
dc.contributor.author
Ramos, Rafel
dc.contributor.author
Sanchez-Santos, MT
dc.contributor.author
Prieto-Alhambra, Dani
dc.contributor.author
Spector, Timothy D.
dc.contributor.author
Hart, DJ
dc.contributor.author
Arden, Nigel K.
dc.date.accessioned
2025-10-24T10:58:36Z
dc.date.available
2025-10-24T10:58:36Z
dc.date.issued
2018-06-19T08:23:13Z
dc.date.issued
2018-06-19T08:23:13Z
dc.date.issued
2017-06-09
dc.identifier
Garcia-Gil M, Reyes C, Ramos R, Sanchez-Santos MT, Prieto-Alhambra D, Spector TD, et al. Serum Lipid Levels and Risk Of Hand Osteoarthritis: the Chingford Prospective Cohort Study. Sci Rep. 2017Jun 9;7(1):3147.doi: 10.1038/s41598-017-03317-4
dc.identifier
https://hdl.handle.net/11351/3533
dc.identifier
10.1038/s41598-017-03317-4
dc.identifier.uri
https://hdl.handle.net/11351/3533
dc.description.abstract
Serum Lipid Levels; Osteoarthritis; Cohort Studies
dc.description.abstract
Nivells de lípids sèrics; Osteoartritis; Estudis de cohorts
dc.description.abstract
Niveles de lípidos séricos; Osteoartritis; Estudios de cohortes
dc.description.abstract
The development of hand osteoarthritis (HOA) could be linked to hyperlipidaemia. No longitudinal studies have addressed the relationship between serum lipid profile and HOA. The study aim was to determine the association between serum lipid profile and the incidence of radiographic hand osteoarthritis (RHOA). All women in a prospective population-based cohort from the Chingford study with available baseline lipid measurements and without RHOA on a baseline were included. Study outcome was the incidence of RHOA in year 11 of follow-up. Serum lipid profile variables were analysed as continuous variables and categorised into quartiles. The association between serum lipid profile and RHOA was modeled using multivariable logistic regression. Overall RHOA incidence was 51.6% (45.7-57.4%). An inverse association between HDL cholesterol levels and the incidence of RHOA was observed by quartile: OR of 0.36 [95%CI 0.17-0.75], 0.52 [95%CI 0.26-1.06], and 0.48 [95%CI 0.22-1.03]. Triglycerides levels showed a significant trend. No relationship was found with total or LDL cholesterol. Higher levels of HDL cholesterol appear to protect against RHOA after 11 years of follow-up. More research is needed to elucidate HOA risk factors, the mechanisms related to the lipid pathway, and the effects of lipid-lowering agents on reducing the incidence of OA.
dc.format
application/pdf
dc.publisher
Nature Publishing Group
dc.relation
Scientific Reports;7(1)
dc.relation
http://www.nature.com/articles/s41598-017-03317-4
dc.rights
Atribución-NoComercial-SinDerivadas 3.0 España
dc.rights
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Lípids de la sang
dc.subject
Raonament basat en casos
dc.subject
CHEMICALS AND DRUGS::Lipids
dc.subject
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/blood
dc.subject
DISEASES::Musculoskeletal Diseases::Joint Diseases::Arthritis::Osteoarthritis
dc.subject
PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Epidemiologic Studies::Analytical Epidemiology::Observational Studies as Topic::Cohort Studies
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::lípidos
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/sangre
dc.subject
ENFERMEDADES::enfermedades musculoesqueléticas::artropatías::artritis::osteoartritis
dc.subject
SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::estudios epidemiológicos::epidemiología analítica::estudios observacionales como asunto::estudios de cohortes
dc.title
Serum Lipid Levels and Risk Of Hand Osteoarthritis: the Chingford Prospective Cohort Study
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
