dc.contributor
Institut Català de la Salut
dc.contributor
[Crone V] Department of Intensive Care, Holbæk Hospital, Holbæk, Denmark. [Møller MH, Perner A] Department of Intensive Care, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. [Granholm A] Department of Intensive Care, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark. Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. [Alhazzani W] Scientific Research Centre, Ministry of Defence Health Services, Riyadh, Saudi Arabi. Department of Critical Care Medicine, King Saud University, Riyadh, Saudi Arabia. [Al-Fares A] Department of Anaesthesia, Critical Care Medicine and Pain Medicine, Al-Amiri Hospital, Ministry of Health, Kuwait City, Kuwait. [Ferrer R] Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Al-Fares, Abdulrahman
dc.contributor.author
Crone, Vera
dc.contributor.author
Møller, Morten Hylander
dc.contributor.author
Granholm, Anders
dc.contributor.author
Perner, Anders
dc.contributor.author
Alhazzani, Waleed
dc.contributor.author
Ferrer, Ricard
dc.date.accessioned
2025-12-16T06:15:30Z
dc.date.available
2025-12-16T06:15:30Z
dc.date.issued
2025-12-15T13:21:15Z
dc.date.issued
2025-12-15T13:21:15Z
dc.identifier
Crone V, Møller MH, Granholm A, Perner A, Alhazzani W, Al-Fares A, et al. Selected Serious Adverse Events in a Cohort of Adult ICU Patients: Protocol for a Sub-Study of the PATIENCE Cohort. Acta Anaesthesiol Scand. 2025 Oct;69(9):e70125.
dc.identifier
http://hdl.handle.net/11351/14147
dc.identifier
10.1111/aas.70125
dc.identifier
001586572700003
dc.identifier.uri
http://hdl.handle.net/11351/14147
dc.description.abstract
Adverse events; Adult patients; ICU
dc.description.abstract
Esdeveniments adversos; Pacients adults; UCI
dc.description.abstract
Eventos adversos; Pacientes adultos; UCI
dc.description.abstract
Background
Serious adverse events (SAEs) are a relevant patient safety concern in critically ill patients, yet epidemiological data on their occurrence in the intensive care unit (ICU) remain limited. This sub-study of the PATIENCE cohort study aims to describe the occurrence of selected SAEs in adult ICU patients with and without prokinetic treatment.
Methods
This is a protocol and statistical analysis plan for a post hoc sub-study of the “Prokinetic agents in adult intensive care unit patients—An international inception cohort study (PATIENCE)” which has included 1440 acutely admitted adult ICU patients from 11 countries.
The primary outcome is the proportion of patients experiencing selected SAEs, assessed according to exposure to prokinetic treatment. Secondary outcomes include the proportion of patients experiencing each specific SAE, their distribution by treatment duration, and timing in relation to ICU admission and prokinetic use. Furthermore, patient characteristics for those with and without the SAEs will be described. Data will be presented descriptively.
Conclusion
This sub-study will use data from the international PATIENCE cohort study to provide epidemiological data on the occurrence of SAEs potentially related to prokinetic use in adult ICU patients.
dc.format
application/pdf
dc.relation
Acta Anaesthesiologica Scandinavica;69(9)
dc.relation
https://doi.org/10.1111/aas.70125
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Medicaments gastrointestinals - Ús terapèutic - Efectes secundaris
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Unitats de cures intensives
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Malalts en estat crític
dc.subject
HEALTH CARE::Health Care Facilities, Manpower, and Services::Health Facilities::Hospital Units::Intensive Care Units
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DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Critical Illness
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CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Gastrointestinal Agents
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Other subheadings::Other subheadings::Other subheadings::/adverse effects
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ATENCIÓN DE SALUD::instalaciones, servicios y personal de asistencia sanitaria::centros sanitarios::unidades hospitalarias::unidades de cuidados intensivos
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ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::enfermedad crítica
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::fármacos gastrointestinales
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
dc.title
Selected Serious Adverse Events in a Cohort of Adult ICU Patients: Protocol for a Sub-Study of the PATIENCE Cohort
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
