dc.contributor
Institut Català de la Salut
dc.contributor
[Meijs-Hermanns P] Maastricht University Medical Center, Department of Pathology, Maastricht, The Netherlands. [Werner HMJ] Maastricht University Medical Center, Department of Obstetrics and Gynecology, Maastricht, The Netherlands. GROW-School for Oncology and Reproduction, Maastricht, The Netherlands. [Kooreman L] Maastricht University Medical Center, Department of Pathology, Maastricht, The Netherlands. GROW-School for Oncology and Reproduction, Maastricht, The Netherlands. [Bretová P, Weinberger V] University Hospital Brno and Masaryk University, Department of Gynecology and Obstetrics, Brno, Czech Republic. [Vrede S] Radboud University Medical Center, Department of Obstetrics and Gynecology, Nijmegen, The Netherlands. [Gil-Moreno A] CIBERONC, Universitat Autònoma de Barcelona, Bellaterra, Spain. Grup de Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBERONC, Barcelona, Spain. Servei de Ginecologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Meijs-Hermanns, Puk
dc.contributor.author
werner, henrica
dc.contributor.author
Kooreman, Loes
dc.contributor.author
Bretová, Petra
dc.contributor.author
Weinberger, Vit
dc.contributor.author
Vrede, Stephanie
dc.contributor.author
Gil-Moreno, Antonio
dc.date.accessioned
2025-05-03T13:42:00Z
dc.date.available
2025-05-03T13:42:00Z
dc.date.issued
2025-04-22T06:48:45Z
dc.date.issued
2025-04-22T06:48:45Z
dc.identifier
Meijs-Hermanns P, Werner HMJ, Kooreman L, Bretová P, Weinberger V, Vrede S, et al. Improving pre-operative binary grading: relevance of p53 and PR expression in grade 2 endometrioid endometrial carcinoma. Int J Gynecol Cancer. 2025 Apr;35(4):101682.
dc.identifier
http://hdl.handle.net/11351/12968
dc.identifier
10.1016/j.ijgc.2025.101682
dc.identifier.uri
http://hdl.handle.net/11351/12968
dc.description.abstract
Endometrial carcinoma; Grade 2; Progesterone receptor
dc.description.abstract
Carcinoma de endometrio; Grado 2; Receptor de progesterona
dc.description.abstract
Carcinoma d'endometri; Grau 2; Receptor de progesterona
dc.description.abstract
Objective
This study aimed to evaluate the association between pre-operative progesterone receptor (PR) and p53 expression and prognosis in pre-operative grade 2 endometrioid endometrial carcinoma compared with grade 1 and grade 3 carcinomas.
Methods
Three European endometrial carcinoma cohort studies were included. Patients with pre-operative grade 2 endometrioid carcinoma and known pre-operative PR and p53 status were included (n = 400), as were patients with pre-operative grade 1 (n = 602) or grade 3 (n = 148) endometrioid carcinomas. Kaplan-Meier and Cox regression analyses were performed to analyze disease-specific and disease-free survival.
Results
Patients with pre-operative grade 2 endometrial carcinoma and wild-type p53 plus PR-positive expression showed a similar 7-year disease-specific survival to grade 1 endometrial carcinoma patients (95.8% vs 97.5%, p = .13), while the 7-year disease-specific survival of patients with grade 2 endometrial carcinoma with p53 aberrant and/or negative PR expression (83.5%) was significantly lower (p < .001). The combination of these markers was an independent prognostic factor in multivariate Cox regression analyses.
Conclusions
The prognostic impact of pre-operative p53 and PR expression in patients with grade 2 endometrioid endometrial carcinoma supports a modified binary grading system in which grade 2 patients should be pre-operatively classified as low- or high-grade depending on p53 and PR expression.
dc.format
application/pdf
dc.relation
International Journal of Gynecological Cancer;35(4)
dc.relation
https://doi.org/10.1016/j.ijgc.2025.101682
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Endometri - Càncer - Cirurgia
dc.subject
Endometri - Càncer - Prognosi
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Progesterona - Receptors
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Proteïnes supressores de tumors
dc.subject
DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Female::Uterine Neoplasms::Endometrial Neoplasms
dc.subject
Other subheadings::Other subheadings::Other subheadings::/surgery
dc.subject
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Adenocarcinoma::Carcinoma, Endometrioid
dc.subject
Other subheadings::Other subheadings::Other subheadings::/surgery
dc.subject
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Poly-ADP-Ribose Binding Proteins::Tumor Suppressor Protein p53
dc.subject
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Receptors, Cytoplasmic and Nuclear::Receptors, Steroid::Receptors, Progesterone
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Neoplasm Grading
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ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales femeninos::neoplasias uterinas::neoplasias endometriales
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
dc.subject
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias glandulares y epiteliales::carcinoma::adenocarcinoma::carcinoma endometrioide
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas transportadoras::proteínas de unión a poli-ADP-ribosa::proteína supresora de tumor p53
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::receptores citoplásmicos y nucleares::receptores de esteroides::receptores de progesterona
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::gradación neoplásica
dc.title
Improving pre-operative binary grading: relevance of p53 and PR expression in grade 2 endometrioid endometrial carcinoma
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
