dc.contributor
Institut Català de la Salut
dc.contributor
[Boada-Pérez M] Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Berastegui C, Monforte V] Grup de Recerca de Nefrologia i Trasplantament Renal, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Unitat de Trasplantament Pulmonar, Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. [Erro M] Grup de Recerca de Nefrologia i Trasplantament Renal, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Department of Pulmonary Medicine, Puerta de Hierro Majadahonda University Hospital, Majadahonda, Madrid, Spain. [Ussetti P] Department of Pulmonary Medicine, Puerta de Hierro Majadahonda University Hospital, Majadahonda, Madrid, Spain. [Crespo E, Donadeu L] Grup de Recerca de Nefrologia i Trasplantament Renal, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Bestard O] Grup de Recerca de Nefrologia i Trasplantament Renal, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Unitat de Trasplantament Renal, Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Revilla-Loez E] Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Unitat de Trasplantament Pulmonar, Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Gómez-Ollés S] Servei de Pneumologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Grup de Recerca de Nefrologia i Trasplantament Renal, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Boada Perez, Meritxell
dc.contributor.author
Berastegui Garcia, Cristina
dc.contributor.author
Erro, Marta
dc.contributor.author
Gomez-Olles, Susana
dc.contributor.author
Ussetti, Piedad
dc.contributor.author
Crespo, Elena
dc.contributor.author
Donadeu Casassas, Laura
dc.contributor.author
Bestard, Oriol
dc.contributor.author
Revilla Lopez, Eva
dc.contributor.author
Monforte, Victor
dc.date.accessioned
2025-05-03T13:40:30Z
dc.date.available
2025-05-03T13:40:30Z
dc.date.issued
2025-03-20T13:33:48Z
dc.date.issued
2025-03-20T13:33:48Z
dc.date.issued
2025-01-22
dc.identifier
Boada-Pérez M, Berastegui C, Erro M, Ussetti P, Crespo E, Donadeu L, et al. Discordance between humoral and cellular immune responses to cytomegalovirus infection in CMV seropositive patients awaiting lung transplantation. Front Immunol. 2025 Jan 22;15:1445553.
dc.identifier
http://hdl.handle.net/11351/12802
dc.identifier
10.3389/fimmu.2024.1445553
dc.identifier
001413073800001
dc.identifier.uri
http://hdl.handle.net/11351/12802
dc.description.abstract
Humoral immune response; Immunocompromised; Infection risk
dc.description.abstract
Respuesta inmune humoral; Inmunocomprometido; Riesgo de infección
dc.description.abstract
Resposta immune humoral; Immunocompromès; Risc d'infecció
dc.description.abstract
Introduction: Risk stratification for CMV infection in lung transplantation (LT) currently relies on determining donor and recipient CMV IgG before transplantation. However, it has been observed that some patients who test positive for CMV-specific humoral response before kidney transplantation (KT) exhibit a weak or absent CMV-specific cellular response. The significance of this observation in LT is still unknown.
Methods: This prospective, multicenter, observational study evaluated the agreement between CMV IgG serology and specific cell-mediated response (specific T cell Enzyme-Linked ImmunoSpot Assay, ELISPOT, against CMV pp65 and IE-1 antigens) in 121 patients on the waiting list for LT.
Results: One hundred and four (86%) patients were seropositive for CMV. Discordant humoral and cellular immunologic responses were observed, 29% of seropositive patients had a weak ELISPOT response to IE-1 and 39% to pp65. In 22% of seropositive patients, there was a weak or no response to both antigens. All seronegative patients did not respond to either antigen.
Conclusions: Therefore, over 20% of CMV seropositive LT candidates showed weak CMV-specific cellular immune responses despite detectable serological memory against CMV. This may be important in assessing the risk of developing a CMV infection after transplantation.
dc.description.abstract
This study was sponsored and funded by Merck Sharp & Dohme (MSD) Spain.
dc.format
application/pdf
dc.publisher
Frontiers Media
dc.relation
Frontiers in Immunology;15
dc.relation
https://doi.org/10.3389/fimmu.2024.1445553
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Citomegalovirus
dc.subject
Immunitat cel·lular
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Pulmons - Trasplantació - Complicacions
dc.subject
DISEASES::Virus Diseases::DNA Virus Infections::Herpesviridae Infections::Cytomegalovirus Infections
dc.subject
PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Adaptive Immunity::Immunity, Cellular
dc.subject
PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Adaptive Immunity::Immunity, Humoral
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Thoracic Surgical Procedures::Pulmonary Surgical Procedures::Lung Transplantation
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Other subheadings::Other subheadings::Other subheadings::/adverse effects
dc.subject
ENFERMEDADES::virosis::infecciones por virus ADN::infecciones por Herpesviridae::infecciones por Citomegalovirus
dc.subject
FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad adaptativa::inmunidad celular
dc.subject
FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad adaptativa::inmunidad humoral
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos torácicos::procedimientos quirúrgicos pulmonares::trasplante de pulmón
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/efectos adversos
dc.title
Discordance between humoral and cellular immune responses to cytomegalovirus infection in CMV seropositive patients awaiting lung transplantation
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
