dc.contributor
Institut Català de la Salut
dc.contributor
[Loupy A] Université Paris Cité, Institut national de la santé et de la recherche médicale (INSERM) U970, Paris Institute for Transplantation and Organ Regeneration PITOR, Paris, France. Department of Kidney Transplantation, Necker Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France. [Certain A, Racapé M, Ursule-Dufait C, Benbadi K] Université Paris Cité, Institut national de la santé et de la recherche médicale (INSERM) U970, Paris Institute for Transplantation and Organ Regeneration PITOR, Paris, France. [Tangprasertchai NS] CareDx, Brisbane, CA, United States. [Bestard O, Kervella D] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca de Nefrologia i Trasplantament Renal, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Loupy, Alexandre
dc.contributor.author
Certain, Anaïs
dc.contributor.author
Tangprasertchai, Narin
dc.contributor.author
Racapé, Maud
dc.contributor.author
Ursule-Dufait, Cindy
dc.contributor.author
Benbadi, Kawthar
dc.contributor.author
Bestard, Oriol
dc.contributor.author
KERVELLA, Delphine
dc.date.accessioned
2025-02-04T14:39:42Z
dc.date.available
2025-02-04T14:39:42Z
dc.date.issued
2025-02-03T09:27:33Z
dc.date.issued
2025-02-03T09:27:33Z
dc.date.issued
2024-12-17
dc.identifier
Loupy A, Certain A, Tangprasertchai NS, Racapé M, Ursule-Dufait C, Benbadi K, et al. Evaluation of a Decentralized Donor-Derived Cell-Free DNA Assay for Kidney Allograft Rejection Monitoring. Transpl Int. 2024 Dec 17;37:13919.
dc.identifier
https://hdl.handle.net/11351/12513
dc.identifier
10.3389/ti.2024.13919
dc.identifier
001389155300001
dc.identifier.uri
http://hdl.handle.net/11351/12513
dc.description.abstract
Allograft rejection; Liquid biopsy; Non-invasive diagnosis
dc.description.abstract
Rebuig d'al·lograft; Biòpsia líquida; Diagnòstic no invasiu
dc.description.abstract
Rechazo del aloinjerto; Biopsia líquida; Diagnóstico no invasivo
dc.description.abstract
Donor-derived cell-free DNA (dd-cfDNA) is an emerging non-invasive biomarker for allograft injury detection. This study aimed to evaluate a new, decentralized dd-cfDNA testing kit against a centralized dd-cfDNA testing service broadly utilized in the United States. Kidney transplant recipients with decentralized and centralized dd-cfDNA measurements and concomitant kidney allograft biopsies were included in the study. 580 kidney allograft recipients from 3 referral centers were included for 603 total evaluations. Correlation between assays was evaluated using r-squared (r 2) and Spearman's rank correlation test, and associations with rejection using logistic regression analyses and discrimination using area under the curve. Mean dd-cfDNA levels from decentralized and centralized tests were 0.51% ± 0.81% and 0.43% ± 0.78%, respectively. The assays were highly correlated, with r 2 = 0.95 and Spearman's rank correlation 0.88 (p < 0.0001). Both tests showed significant association with allograft rejection (p < 0.0001) and good and similar discriminations to predict rejection (AUC: 0.758 for the decentralized and AUC: 0.760 for the centralized dd-cfDNA; p = 0.8466). Consistency between the assays was also confirmed across clinical scenarios including post-transplant timepoint, allograft stability, and allograft rejection subcategories. This decentralized dd-cfDNA assessment demonstrates high accuracy and value to non-invasively monitor kidney recipients.
dc.description.abstract
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. OrganX Foundation.
dc.format
application/pdf
dc.publisher
Frontiers Media
dc.relation
Transplant International;37
dc.relation
https://doi.org/10.3389/ti.2024.13919
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Ronyons - Trasplantació
dc.subject
Rebuig (Biologia)
dc.subject
Marcadors bioquímics
dc.subject
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::Cell-Free Nucleic Acids
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Transplantation::Organ Transplantation::Surgical Procedures, Operative::Kidney Transplantation
dc.subject
CHEMICALS AND DRUGS::Biological Factors::Biomarkers
dc.subject
PHENOMENA AND PROCESSES::Immune System Phenomena::Transplantation Immunology::Host vs Graft Reaction::Graft Rejection
dc.subject
NAMED GROUPS::Persons::Transplant Recipients
dc.subject
ANATOMY::Body Regions::Transplants::Allografts
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ácidos nucleicos libres de células
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::trasplante::trasplante de órganos::intervenciones quirúrgicas::trasplante de riñón
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores
dc.subject
FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunología del trasplante::reacción huésped contra injerto::rechazo del injerto
dc.subject
DENOMINACIONES DE GRUPOS::personas::receptores de trasplantes
dc.subject
ANATOMÍA::regiones corporales::trasplantes::aloinjertos
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::técnicas citológicas::citodiagnóstico::biopsia
dc.title
Evaluation of a Decentralized Donor-Derived Cell-Free DNA Assay for Kidney Allograft Rejection Monitoring
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
