dc.contributor
Institut Català de la Salut
dc.contributor
[Loeb E] Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servicio de Neumología, Centro Médico Teknon, Grupo Quironsalud, Barcelona, Spain. [Zock JP] National Institute for Public Health and the Environment (RIVM), BA Bilthoven, The Netherlands. [Miravitlles M] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Rodríguez E, Ferrer Sancho J] Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [Kromhout H] Institute for Risk Assessment Sciences, Utrecht University, CM Utrecht, The Netherlands. [Vermeulen R] Institute for Risk Assessment Sciences, Utrecht University, CM Utrecht, The Netherlands. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, GA Utrecht, The Netherlands
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Loeb, Eduardo
dc.contributor.author
Zock, Jan-Paul
dc.contributor.author
Rodríguez González, Esther
dc.contributor.author
Kromhout, Hans
dc.contributor.author
Vermeulen, Roel
dc.contributor.author
Miravitlles, Marc
dc.contributor.author
Ferrer Sancho, Jaume
dc.date.accessioned
2024-12-17T01:43:55Z
dc.date.available
2024-12-17T01:43:55Z
dc.date.issued
2024-12-16T08:03:52Z
dc.date.issued
2024-12-16T08:03:52Z
dc.date.issued
2024-09-24
dc.identifier
Loeb E, Zock JP, Miravitlles M, Rodríguez E, Kromhout H, Vermeulen R, et al. Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population. Toxics. 2024 Oct;12(10):689.
dc.identifier
https://hdl.handle.net/11351/12329
dc.identifier
10.3390/toxics12100689
dc.identifier
001342633200001
dc.identifier.uri
http://hdl.handle.net/11351/12329
dc.description.abstract
Chronic obstructive pulmonary disease; Computed tomography; Occupational exposures
dc.description.abstract
Enfermedad pulmonar obstructiva crónica; Tomografía computarizada; Exposiciones ocupacionales
dc.description.abstract
Malaltia pulmonar obstructiva crònica; Tomografia computada; Exposicions ocupacionals
dc.description.abstract
Self-reported occupational exposure was previously associated with COPD in the Spanish population. This study aimed to analyse the relationship between occupational exposure to various chemical and biological agents, COPD, emphysema, and the bronchial wall area, which was determined by lung computed tomography (CT) in 226 individuals with COPD and 300 individuals without COPD. Lifetime occupational exposures were assessed using the ALOHA(+) job exposure matrix, and CT and spirometry were also performed. COPD was associated with high exposure to vapours, gases, dust and fumes (VGDF) (OR 2.25 95% CI 1.19-4.22), biological dust (OR 3.01 95% CI 1.22-7.45), gases/fumes (OR 2.49 95% CI 1.20-5.17) and with exposure to various types of solvents. High exposure to gases/fumes, chlorinated solvents and metals (coefficient 8.65 95% CI 1.21-16.09, 11.91 95%CI 0.46- 23.36, 14.45 95% CI 4.42-24.49, respectively) and low exposure to aromatic solvents (coefficient 8.43 95% CI 1.16-15.70) were associated with a low 15th percentile of lung density indicating emphysema. We conclude that occupational exposure to several specific agents is associated with COPD and emphysema in the Spanish population.
dc.description.abstract
Both this study and EPISCAN II were sponsored by Glaxo Smith-Kline (GSK).
dc.format
application/pdf
dc.relation
Toxics;12(10)
dc.relation
https://doi.org/10.3390/toxics12100689
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Pulmons - Malalties obstructives - Tomografia
dc.subject
Pulmons - Malalties obstructives - Diagnòstic
dc.subject
Malalties professionals
dc.subject
DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Pulmonary Disease, Chronic Obstructive
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Image Interpretation, Computer-Assisted::Tomography, X-Ray Computed
dc.subject
HEALTH CARE::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Occupational Exposure
dc.subject
ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares obstructivas::enfermedad pulmonar obstructiva crónica
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::interpretación de imágenes asistida por ordenador::tomografía computarizada por rayos X
dc.subject
ATENCIÓN DE SALUD::ambiente y salud pública::salud pública::contaminación ambiental::exposición ambiental::exposición profesional
dc.title
Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
