dc.contributor
Institut Català de la Salut
dc.contributor
[Saini KS] Fortrea Inc., Durham, NC, United States. Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom. [Somara S, Thatai P] Fortrea Inc., Durham, NC, United States. [Ko HC, Wallen ZD] Labcorp Oncology, Durham, NC, United States. [Quintana A] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Somara, Sasikala
dc.contributor.author
Ko, Heidi
dc.contributor.author
Thatai, Purva
dc.contributor.author
Wallen, Zachary
dc.contributor.author
Saini, Kamal S.
dc.contributor.author
Quintana, Angela
dc.date.accessioned
2025-10-25T05:37:26Z
dc.date.available
2025-10-25T05:37:26Z
dc.date.issued
2024-12-04T08:44:44Z
dc.date.issued
2024-12-04T08:44:44Z
dc.date.issued
2024-10-08
dc.identifier
Saini KS, Somara S, Ko HC, Thatai P, Quintana A, Wallen ZD, et al. Biomarkers in head and neck squamous cell carcinoma: unraveling the path to precision immunotherapy. Front Oncol. 2024 Oct 8;14:1473706.
dc.identifier
https://hdl.handle.net/11351/12309
dc.identifier
10.3389/fonc.2024.1473706
dc.identifier
001337479900001
dc.identifier.uri
http://hdl.handle.net/11351/12309
dc.description.abstract
Diagnostic biomarker; Head and neck cancer; Squamous cell cancer
dc.description.abstract
Biomarcador diagnóstico; Cáncer de cabeza y cuello; Cáncer de células escamosas
dc.description.abstract
Biomarcador diagnòstic; Càncer de cap i coll; Càncer de cèl·lules escamoses
dc.description.abstract
Recent strides in understanding the molecular underpinnings of head and neck cancers have sparked considerable interest in identifying precise biomarkers that can enhance prognostication and enable personalized treatment strategies. Immunotherapy has particularly revolutionized the therapeutic landscape for head and neck squamous cell carcinoma, offering new avenues for treatment. This review comprehensively examines the application and limitations of the established and emerging/novel biomarkers for head and neck squamous cell carcinoma. Established biomarkers, including well-characterized genetic mutations, protein expressions, and clinical factors, have been extensively studied and validated in clinical practice. Novel biomarkers identified through molecular analyses, including novel genetic alterations, immune-related markers, and molecular signatures, are currently being investigated and validated in preclinical and clinical settings. Biomarkers hold the potential to deepen our understanding of head and neck squamous cell carcinoma biology and guide therapeutic strategies. The evolving paradigm of predictive biomarkers facilitates the study of individual responses to specific treatments, including targeted therapy and immunotherapy.
dc.format
application/pdf
dc.publisher
Frontiers Media
dc.relation
Frontiers in Oncology;14
dc.relation
https://doi.org/10.3389/fonc.2024.1473706
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Marcadors tumorals
dc.subject
Medicina personalitzada
dc.subject
Coll - Càncer - Immunoteràpia
dc.subject
Cap - Càncer - Immunoteràpia
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Precision Medicine
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy
dc.subject
DISEASES::Neoplasms::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms::Squamous Cell Carcinoma of Head and Neck
dc.subject
Other subheadings::Other subheadings::/therapy
dc.subject
CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::medicina de precisión
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia
dc.subject
ENFERMEDADES::neoplasias::neoplasias::neoplasias por localización::neoplasias de cabeza y cuello::carcinoma de células escamosas de cabeza y cuello
dc.subject
Otros calificadores::Otros calificadores::/terapia
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales
dc.title
Biomarkers in head and neck squamous cell carcinoma: unraveling the path to precision immunotherapy
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
