dc.contributor
Institut Català de la Salut
dc.contributor
[Nadal-Barón P, Trejo-Zahinos J, Pérez-Ugarte A] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Arando M] Unitat d’Infeccions de Transmissió Sexual, Drassanes-Vall d’Hebron Hospital Universitari, Barcelona, Spain. Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Barberan-Masegosa A] Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Bernat-Sole M, Villatoro AM, Alcubilla P, Hoyos-Mallecot Y] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Sulleiro E, Gonzalez-López JJ, Antón A, Larrosa MN] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Infectious Diseases CIBER (CIBERINFEC), Carlos III Health, Madrid, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Trejo-Zahinos, Jesus
dc.contributor.author
Barberan-Masegosa, Alicia
dc.contributor.author
Bernat, Marta
dc.contributor.author
Perez-Ugarte, Arantxa
dc.contributor.author
Villatoro, Ana Maria
dc.contributor.author
Alcubilla, Pilar
dc.contributor.author
Nadal-Barón, Patricia
dc.contributor.author
Arando, Maider
dc.contributor.author
Sulleiro, Elena
dc.contributor.author
González-López, Juan José
dc.contributor.author
Hoyos Mallecot, Yannick
dc.contributor.author
Antón Pagarolas, Andrés
dc.contributor.author
Larrosa, María Nieves
dc.date.accessioned
2025-10-24T10:34:38Z
dc.date.available
2025-10-24T10:34:38Z
dc.date.issued
2024-11-11T07:31:30Z
dc.date.issued
2024-11-11T07:31:30Z
dc.date.issued
2024-10-08
dc.identifier
Nadal-Barón P, Trejo-Zahinos J, Arando M, Barberan-Masegosa A, Bernat-Sole M, Pérez-Ugarte A, et al. High increase of Nichols-like clade circulating Treponema pallidum subsp. pallidum in Barcelona from 2021 to 2023. Sci Rep. 2024 Oct 8;14:23419.
dc.identifier
https://hdl.handle.net/11351/12206
dc.identifier
10.1038/s41598-024-74355-y
dc.identifier
001331683000078
dc.identifier.uri
https://hdl.handle.net/11351/12206
dc.description.abstract
Treponema pallidum; Phylogeny; Syphilis
dc.description.abstract
Treponema pallidum; Filogenia; Sífilis
dc.description.abstract
Treponema pallidum; Filogènia; Sífilis
dc.description.abstract
Worldwide, more than 90% of contemporary syphilis strains belong to SS14-like clade. This study aimed to describe the molecular profile of circulating Treponema pallidum subsp. pallidum (TPA) strains in Barcelona, Spain, from 2021 to 2023 building upon our report in 2015 which showed that 94.8% of typed strains belonged to the SS14 clade. Multilocus sequence typing (MLST) was conducted on TPA-positive samples obtained from swab samples by sequencing the tp0136, tp0548, and tp0705 loci. Strains were classified as Nichols-like or SS14-like clade. Macrolide and tetracycline resistance‑associated mutations were determined through analysis of 23S rDNA and 16S rRNA gene sequences. Of the 96 typeable samples, 47.9% belonged to SS14-like and 52.1% to the Nichols-like. Fourteen haplotypes were identified, with ST26 representing 43.8% of the samples, distributed across 11 haplotypes in the SS14-like and 3 haplotypes in the Nichols-like. All the samples showed macrolide resistance-associated mutations, while none exhibited tetracycline-associated mutations. Our findings revealed a substantial shift in the proportion of TPA clades within the Barcelona population from 2021 to 2023, characterized by a higher proportion of Nichols-like strains compared to 2015 and international trends. The varying temporal and geographical trends underscore the need for regular surveillance to understand regional variations in syphilis and strengthen control programs.
dc.format
application/pdf
dc.publisher
Nature Portfolio
dc.relation
Scientific Reports;14
dc.relation
https://doi.org/10.1038/s41598-024-74355-y
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Anomalies cromosòmiques
dc.subject
Sífilis - Epidemiologia
dc.subject
Microorganismes - Resistència als medicaments
dc.subject
PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Variation::Mutation
dc.subject
ORGANISMS::Bacteria::Bacteria::Spirochaetales::Spirochaetaceae::Treponema::Treponema pallidum
dc.subject
DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections::Treponemal Infections::Syphilis
dc.subject
PHENOMENA AND PROCESSES::Microbiological Phenomena::Bacterial Physiological Phenomena::Drug Resistance, Bacterial
dc.subject
FENÓMENOS Y PROCESOS::fenómenos genéticos::variación genética::mutación
dc.subject
ORGANISMOS::Bacteria::Bacteria::Spirochaetales::Spirochaetaceae::Treponema::Treponema pallidum
dc.subject
ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias gramnegativas::infecciones por Treponema::sífilis
dc.subject
FENÓMENOS Y PROCESOS::fenómenos microbiológicos::fenómenos fisiológicos bacterianos::farmacorresistencia bacteriana
dc.title
High increase of Nichols-like clade circulating Treponema pallidum subsp. pallidum in Barcelona from 2021 to 2023
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
