dc.contributor
Institut Català de la Salut
dc.contributor
[Zabalza A, Pappolla A, Comabella M, Malhotra S] Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Montalban X] Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Faculty of Medicine, University of Vic - Central University of Catalonia (UVicUCC), Vic, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Zabalza, Ana
dc.contributor.author
Pappolla, Agustin
dc.contributor.author
Comabella Lopez, Manuel
dc.contributor.author
Malhotra Sareen, Sunny
dc.contributor.author
Montalban, Xavier
dc.date.issued
2024-10-30T07:00:42Z
dc.date.issued
2024-10-30T07:00:42Z
dc.date.issued
2024-08-29
dc.identifier
Zabalza A, Pappolla A, Comabella M, Montalban X, Malhotra S. MiRNA-based therapeutic potential in multiple sclerosis. Front Immunol. 2024;15:1441733.
dc.identifier
https://hdl.handle.net/11351/12152
dc.identifier
10.3389/fimmu.2024.1441733
dc.identifier
001309844600001
dc.description.abstract
Biomarkers; MicroRNAs; Multiple sclerosis
dc.description.abstract
Biomarcadors; MicroRNAs; Esclerosi múltiple
dc.description.abstract
Biomarcadores; MicroRNAs; Esclerosis múltiple
dc.description.abstract
This review will briefly introduce microRNAs (miRNAs) and dissect their contribution to multiple sclerosis (MS) and its clinical outcomes. For this purpose, we provide a concise overview of the present knowledge of MS pathophysiology, biomarkers and treatment options, delving into the role of selectively expressed miRNAs in clinical forms of this disease, as measured in several biofluids such as serum, plasma or cerebrospinal fluid (CSF). Additionally, up-to-date information on current strategies applied to miRNA-based therapeutics will be provided, including miRNA restoration therapy (lentivirus expressing a specific type of miRNA and miRNA mimic) and miRNA inhibition therapy such as antisense oligonucleotides, small molecules inhibitors, locked nucleic acids (LNAs), anti-miRNAs, and antagomirs. Finally, it will highlight future directions and potential limitations associated with their application in MS therapy, emphasizing the need for improved delivery methods and validation of therapeutic efficacy
dc.description.abstract
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. SM was supported by the grant from Instituto Salud Carlos III (PI20/01697) and cofunded by the European Union.
dc.format
application/pdf
dc.publisher
Frontiers Media
dc.relation
Frontiers in Immunology;15
dc.relation
https://doi.org/10.3389/fimmu.2024.1441733
dc.relation
info:eu-repo/grantAgreement/ES/PE2017-2020/PI20%2F01697
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Teràpia genètica
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Esclerosi múltiple - Tractament
dc.subject
DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis
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Other subheadings::Other subheadings::/therapy
dc.subject
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs
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ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Genetic Therapy
dc.subject
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple
dc.subject
Otros calificadores::Otros calificadores::/terapia
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::elementos antisentido (genética)::ARN antiparalelo::microARN
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::terapia genética
dc.title
MiRNA-based therapeutic potential in multiple sclerosis
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
