dc.contributor
Institut Català de la Salut
dc.contributor
[Tur-Martínez J] Departament de Cirurgia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Department of Surgery, Complex Hospitalari Universitari Moisès Broggi, Sant Joan Despí, Spain. [Rodríguez-Santiago J] Department of Surgery, University Hospital Mútua Terrassa, Terrassa, Spain. [Osorio J] Department of Surgery, Hospital Clínic de Barcelona, Barcelona, Spain. [Miró M] Department of Surgery, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain. [Yarnoz C] Department of Surgery, Hospital Universitario de Navarra, Universidad Pública de Navarra, Pamplona, Spain. [Jofra M] Servei de Cirurgia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Aldeano A] Department of Surgery, Hospital General de Granollers, Granollers, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Tur-Martínez, Jaume
dc.contributor.author
Rodriguez Santiago, Joaquin
dc.contributor.author
Osorio, Javier
dc.contributor.author
Miró, Mònica
dc.contributor.author
Yárnoz, María Concepción
dc.contributor.author
Jofra Castells, Mariona
dc.contributor.author
Aldeano, Aurora
dc.date.accessioned
2025-10-24T10:21:59Z
dc.date.available
2025-10-24T10:21:59Z
dc.date.issued
2024-07-04T09:45:35Z
dc.date.issued
2024-07-04T09:45:35Z
dc.date.issued
2024-06-11
dc.identifier
Tur-Martínez J, Rodríguez-Santiago J, Osorio J, Miró M, Yarnoz C, Jofra M, et al. Prognostic Relevance of Preoperative Immune, Inflammatory, and Nutritional Biomarkers in Patients Undergoing Gastrectomy for Resectable Gastric Adenocarcinoma: An Observational Multicentre Study. Cancers (Basel). 2024 Jun 11;16(12):2188.
dc.identifier
https://hdl.handle.net/11351/11664
dc.identifier
10.3390/cancers16122188
dc.identifier.uri
https://hdl.handle.net/11351/11664
dc.description.abstract
Gastric cancer; Preoperative biomarker; Preoperative immune score
dc.description.abstract
Cáncer gástrico; Biomarcador preoperatorio; Puntuación inmunológico preoperatorio
dc.description.abstract
Càncer gàstric; Biomarcador preoperatori; Puntuació immunològica preoperatòria
dc.description.abstract
Background: The aim of this study was to evaluate different preoperative immune, inflammatory, and nutritional scores and their best cut-off values as predictors of poorer overall survival (OS) and disease-free survival (DFS) in patients who underwent curative gastric cancer resection. Methods: This was a retrospective observational multicentre study based on data of the Spanish EURECCA Esophagogastric Cancer Registry. Time-dependent Youden index and log-rank test were used to obtain the best cut-offs of 18 preoperative biomarkers for OS and DFS. An adjusted Cox model with variables selected by bootstrapping was used to identify the best preoperative biomarkers, which were also analysed for every TNM stage. Results: High neutrophil-to-lymphocyte ratio (NLR), high monocyte systemic inflammation index (moSII), and low prognostic nutritional index (PNI) were identified as independent predictors of poor outcome: NLR > 5.91 (HR:1.73; 95%CI [1.23–2.43]), moSII >2027.12 (HR:2.26; 95%CI [1.36–3.78]), and PNI >40.31 (HR:0.75; 95%CI [0.58–0.96]) for 5-year OS and NLR > 6.81 (HR:1.75; 95%CI [1.24–2.45]), moSII > 2027.12 (HR:2.46; 95%CI [1.49–4.04]), and PNI > 40.31 (HR:0.77; 95%CI [0.60,0.97]) for 5-year DFS. These outcomes were maintained in the whole cohort for NLR and moSII (p < 0.05) but not in stage II and for PNI in all tumoral stages. The associations of NLR-PNI and moSII-PNI were also a relevant prognostic factor for OS. Conclusions: High NLR, high moSII (for stages I and III), and low PNI (regardless of tumour stage) were the most promising preoperative biomarkers to predict poor OS and DFS in gastric cancer patients treated with curative intent.
dc.format
application/pdf
dc.relation
Cancers;16(12)
dc.relation
https://doi.org/10.3390/cancers16122188
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Estómac - Càncer - Cirurgia
dc.subject
Estómac - Càncer - Prognosi
dc.subject
Marcadors bioquímics
dc.subject
CHEMICALS AND DRUGS::Biological Factors::Biomarkers
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DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Stomach Neoplasms
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ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Digestive System Surgical Procedures::Gastrectomy
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ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
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COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores
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ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias gástricas
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos del sistema digestivo::gastrectomía
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
dc.title
Prognostic Relevance of Preoperative Immune, Inflammatory, and Nutritional Biomarkers in Patients Undergoing Gastrectomy for Resectable Gastric Adenocarcinoma: An Observational Multicentre Study
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
