dc.contributor
Institut Català de la Salut
dc.contributor
[Wang k] Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. [Zerdes I] Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Theme Cancer, Karolinska University Hospital and Karolinska Comprehensive Cancer Center, Stockholm, Sweden. [Johansson HJ] Department of Oncology-Pathology, Karolinska Institutet, and Science for Life Laboratory, Stockholm, Sweden. [Sarhan D, Sun Y] Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden. [Kanellis DC] Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. [Mezheyeuski A] Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden. Molecular Oncology Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Wang, Kang
dc.contributor.author
Zerdes, Ioannis
dc.contributor.author
Johansson, Henrik
dc.contributor.author
Sarhan, Dhifaf
dc.contributor.author
Sun, Yizhe
dc.contributor.author
Kanellis, Dimitrios
dc.contributor.author
Mezheyeuski, Artur
dc.date.accessioned
2025-10-25T05:37:28Z
dc.date.available
2025-10-25T05:37:28Z
dc.date.issued
2024-05-15T07:09:54Z
dc.date.issued
2024-05-15T07:09:54Z
dc.date.issued
2024-05-07
dc.identifier
Wang K, Zerdes I, Johansson HJ, Sarhan D, Sun Y, Kanellis DC, et al. Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer. Nat Commun. 2024 May 7;15:3837.
dc.identifier
https://hdl.handle.net/11351/11459
dc.identifier
10.1038/s41467-024-47932-y
dc.identifier.uri
http://hdl.handle.net/11351/11459
dc.description.abstract
Immunometabolism; Breast cancer
dc.description.abstract
Immunometabolisme; Càncer de mama
dc.description.abstract
Inmunometabolismo; Cáncer de mama
dc.description.abstract
Although metabolic reprogramming within tumor cells and tumor microenvironment (TME) is well described in breast cancer, little is known about how the interplay of immune state and cancer metabolism evolves during treatment. Here, we characterize the immunometabolic profiles of tumor tissue samples longitudinally collected from individuals with breast cancer before, during and after neoadjuvant chemotherapy (NAC) using proteomics, genomics and histopathology. We show that the pre-, on-treatment and dynamic changes of the immune state, tumor metabolic proteins and tumor cell gene expression profiling-based metabolic phenotype are associated with treatment response. Single-cell/nucleus RNA sequencing revealed distinct tumor and immune cell states in metabolism between cold and hot tumors. Potential drivers of NAC based on above analyses were validated in vitro. In summary, the study shows that the interaction of tumor-intrinsic metabolic states and TME is associated with treatment outcome, supporting the concept of targeting tumor metabolism for immunoregulation.
dc.description.abstract
Open access funding provided by Karolinska Institute.
dc.format
application/pdf
dc.publisher
Nature Research
dc.relation
Nature communications;15(1)
dc.relation
https://doi.org/10.1038/s41467-024-47932-y
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Mama - Càncer - Aspectes genètics
dc.subject
Regulació genètica
dc.subject
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
dc.subject
Other subheadings::Other subheadings::Other subheadings::/metabolism
dc.subject
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment
dc.subject
ANATOMY::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Therapeutics::Drug Therapy::Chemotherapy, Adjuvant
dc.subject
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
dc.subject
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::microambiente celular::microambiente tumoral
dc.subject
ANATOMÍA::células::células cultivadas::línea celular::línea celular tumoral
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::farmacoterapia::quimioterapia adyuvante
dc.title
Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
