dc.contributor
[Musulen E] Pathology Department, Hospital Universitari General de Catalunya-Grupo QuironSalud, Sant Cugat Del Vallès, Spain. Institut de Recerca Contra La Leucèmia Josep Carreras (IJC), Badalona, Spain. [Gené M] Pathology Department, Hospital Universitari Joan XXIII, Tarragona, Spain. Surgery Department, Programme of Surgery and Morphological Sciences, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain. [Cuatrecasas M] Pathology Department, Hospital Clínic, Barcelona, Spain. Department of Basic Clinical Practice, University of Barcelona (UB), Barcelona, Spain. [Amat I] Pathology Department, Complejo Hospitalario de Navarra, Navarra, Spain. [Veiga JA] Pathology Department, Complejo Hospitalario Universitario de Ferrol, Ferrol, Spain. [Fernández-Aceñero MJ] Pathology Department, Hospital Clínico San Carlos, Madrid, Spain. [Jurado I] Pathology Department, Consorci Sanitari de Terrassa, Terrassa, Spain
dc.contributor
Consorci Sanitari de Terrassa
dc.contributor.author
Musulen, Eva
dc.contributor.author
Cuatrecasas, Miriam
dc.contributor.author
Jurado, Ismael
dc.contributor.author
Hijós, Míriam Gené
dc.contributor.author
amat villegas, irene
dc.contributor.author
VEIGA BARREIRO, JESUS ALBERTO
dc.contributor.author
Fernández-Aceñero, Mª Jesús
dc.date.accessioned
2025-10-24T08:27:55Z
dc.date.available
2025-10-24T08:27:55Z
dc.date.issued
2024-03-25T14:21:09Z
dc.date.issued
2024-03-25T14:21:09Z
dc.identifier
Musulen E, Gené M, Cuatrecasas M, Amat I, Veiga JA, Fernández-Aceñero MJ et al. Gastric metaplasia as a precursor of nonconventional dysplasia in inflammatory bowel disease. Hum Pathol. 2024 Jan;143:50-61.
dc.identifier
https://hdl.handle.net/11351/11240
dc.identifier
10.1016/j.humpath.2023.11.011
dc.identifier.uri
https://hdl.handle.net/11351/11240
dc.description.abstract
Displasia convencional; Metaplasia gástrica; Enfermedad inflamatoria convencional
dc.description.abstract
Conventional dysplasia; Gastric metaplasia; Inflammatory bowel disease
dc.description.abstract
Displàsia convencional; Metaplàsia gàstrica; Malaltia inflamatòria convencional
dc.description.abstract
Gastric metaplasia in colonic mucosa with inflammatory bowel disease (IBD) develops as an adaptation mechanism. The association between gastric metaplasia and nonconventional and/or conventional dysplasia as precursors of colitis-associated colorectal cancer is unknown. To address this question, we retrospectively reviewed a series of 33 IBD colectomies to identify gastric metaplasia in 76 precursor lesions. We obtained 61 nonconventional and 15 conventional dysplasias. Among nonconventional dysplasia, 31 (50.8 %) were low-grade (LGD), 4 (6.5 %) were high-grade (HGD), 9 (14.8 %) had both LGD and HGD, and 17 (27.9 %) had no dysplasia (ND), while 14 (93 %) conventional dysplasias had LGD, and 1 (7 %) had LGD and HGD. Gastric metaplasia was assessed by concomitant immunoexpression of MUC5AC and loss of CDX2 staining. Expression of a p53-mut pattern was considered as a surrogate for gene mutation, and complete loss of MLH1 staining as presence of MLH1 hypermethylation. In nonconventional dysplasia, MUC5AC immunoexpression decreased as the degree of dysplasia increased, being 78 % in LGD and 39 % in HGD (p = 0.006). CDX2 was lost in epithelial glands with high expression of MUC5AC (p < 0.001). The p53-mut pattern was observed in 77 % HGD, 45 % LGD, and in 6 % with ND (p < 0.001). Neither nonconventional nor conventional dysplasia showed complete loss of MLH1 staining. Gastric metaplasia was also present in mucosa adjacent to nonconventional dysplasia with chronic changes or active inflammation. Our results show that gastric metaplasia appears in IBD-inflamed colon mucosa, it is the substrate of most nonconventional dysplasia and occurs prior to p53 alterations.
dc.description.abstract
This work was supported by Roche, Switzerland (activity code: SP210830002).
dc.format
application/pdf
dc.relation
Human Pathology;143
dc.relation
http://doi.org/10.1016/j.humpath.2023.11.011
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Intestins - Inflamació
dc.subject
Còlon - Càncer
dc.subject
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Metaplasia
dc.subject
DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases
dc.subject
DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms
dc.subject
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::metaplasia
dc.subject
ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedad inflamatoria intestinal
dc.subject
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales::neoplasias del colon
dc.title
Gastric metaplasia as a precursor of nonconventional dysplasia in inflammatory bowel disease
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
