dc.contributor
Institut Català de la Salut
dc.contributor
[Santos-García D, Cores Bartolomé C, Feal Painceiras MJ, García Díaz I, Íñiguez Alvarado MC, Paz JM] Complexo Hospitalario Universitario de A Coruña, A Coruña, Spain. [de Deus Fonticoba T] Complexo Hospitalario Universitario de Ferrol, A Coruña, Spain. [Jesús S] Department of Neurology, Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. [Cosgaya M] Department of Neurology, Hospital Clínic de Barcelona, Barcelona, Spain. [Garcia Caldentey J] Department of Neurology, Centro Neurológico Oms 42, Palma de Mallorca, Spain. [Caballol N] Department of Neurology, Consorci Sanitari Integral, Hospital Moisés Broggi, Sant Joan Despí, Barcelona, Spain. [Legarda I] Department of Neurology, Hospital Universitario Son Espases, Palma de Mallorca, Spain. [Hernández Vara J] Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Cabo I] Department of Neurology, Complejo Hospitalario Universitario de Pontevedra (CHOP), Pontevedra, Spain. [López Manzanares L] Department of Neurology, Hospital Universitario La Princesa, Madrid, Spain. [González Aramburu I] Department of Neurology, Hospital Universitario Marqués de Valdecilla – IDIVAL, Santander, Spain. [Ávila Rivera MA] Department of Neurology, Consorci Sanitari Integral, Hospital General de l’Hospitalet, l’Hospitalet de Llobregat, Barcelona, Spain. [Gómez Mayordomo V] Department of Neurology, Institute of Neuroscience, Vithas Madrid La Milagrosa University Hospital, Vithas Hospital Group, Madrid, Spain. [Nogueia V] Department of Neurology, Hospital Universitario Lucus Augusti, Lugo, Spain. [García-Soto JD] Department of Neurology, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Borrué C] Department of Neurology, Hospital Infanta Sofía, Madrid, Spain. [Solano Vila B] Department of Neurology, Institut d’Assistència Sanitària, Institut Català de la Salut, Girona, Spain
dc.contributor
Institut d'Assistència Sanitària
dc.contributor.author
de Deus Fonticoba, Teresa
dc.contributor.author
Cores Bartolomé, Carlos
dc.contributor.author
Feal Painceiras, María
dc.contributor.author
García Díaz, Iago
dc.contributor.author
Íñiguez-Alvarado, Maria Cristina
dc.contributor.author
Jose Manuel, Paz González
dc.contributor.author
Zúniga, Silvia de Jesús
dc.contributor.author
Cosgaya, Marina
dc.contributor.author
Garcia-Caldentey, Juan
dc.contributor.author
Legarda, Ines
dc.contributor.author
Hernández Vara, Jorge
dc.contributor.author
Cabo López, Iria
dc.contributor.author
Gonzalez-Aramburu, Isabel
dc.contributor.author
Ávila Rivera, María A.
dc.contributor.author
Gómez-Mayordomo, Víctor
dc.contributor.author
Nogueira, Víctor
dc.contributor.author
Dotor Garcia-Soto, Julio
dc.contributor.author
Borrué, Carmen
dc.contributor.author
Solano Vila, Berta
dc.contributor.author
Lopez Manzanares, Lydia
dc.contributor.author
Santos García, Diego
dc.contributor.author
Caballol, Nuria
dc.date.accessioned
2025-10-24T10:26:40Z
dc.date.available
2025-10-24T10:26:40Z
dc.date.issued
2023-12-21T12:37:11Z
dc.date.issued
2023-12-21T12:37:11Z
dc.identifier
Santos‐García D, de Deus Fonticoba T, Cores Bartolomé C, Feal Painceiras MJ, García Díaz I, Íñiguez Alvarado MC. et al. Staging Parkinson's disease according to the MNCD classification correlates with caregiver burden. Brain Behav. 2023 Dec;13(12):e3295.
dc.identifier
https://hdl.handle.net/11351/10742
dc.identifier
10.1002/brb3.3295
dc.identifier.uri
https://hdl.handle.net/11351/10742
dc.description.abstract
Malaltia de Parkinson; Cuidador; Símptomes no motors
dc.description.abstract
Parkinson's disease; Caregiver; Non-motor symptoms
dc.description.abstract
Enfermedad de Parkinson; Cuidador; Síntomas no motores
dc.description.abstract
Background and objective: Recently, we demonstrated that staging Parkinson's disease (PD) with a novel simple classification called MNCD, based on four axes (motor, non-motor, cognition, and dependency) and five stages, correlated with disease severity and patients’ quality of life. Here, we analyzed the correlation of MNCD staging with PD caregiver's status. Patients and methods: Data from the baseline visit of PD patients and their principal caregiver recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD total score (from 0 to 12) and MNCD stages (from 1 to 5) in this cross-sectional analysis. Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory-II (BDI-II), PQ-10, and EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Two hundred and twenty-four PD patients (63 ± 9.6 years old; 61.2% males) and their caregivers (58.5 ± 12.1 years old; 67.9% females) were included. The frequency of MNCD stages was 1, 7.6%; 2, 58.9%; 3, 31.3%; and 4–5, 2.2%. A more advanced MNCD stage was associated with a higher score on the ZCBI (p < .0001) and CSI (p < .0001), and a lower score on the PQ-10 (p = .001), but no significant differences were observed in the BDI-II (p = .310) and EUROHIS-QOL8 (p = .133). Moderate correlations were observed between the MNCD total score and the ZCBI (r = .496; p < .0001), CSI (r = .433; p < .0001), and BDI-II (r = .306; p < .0001) in caregivers.Conclusion: Staging PD according to the MNCD classification is correlated with caregivers’ strain and burden.
dc.description.abstract
Fundación Española de Ayuda a la Investigación en Enfermedades Neurodegenerativas y/o de Origen Genético; Alpha Bioresearch; Spanish Ministry of Economy and Competitiveness, Grant/Award Number: PI16/01575
dc.format
application/pdf
dc.publisher
Wiley Open Access
dc.relation
Brain and Behavior;13(12)
dc.relation
https://doi.org/10.1002/brb3.3295
dc.rights
Attribution-ShareAlike 4.0 International
dc.rights
http://creativecommons.org/licenses/by-sa/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Parkinson, Malaltia de
dc.subject
Qualitat de Vida
dc.subject
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Parkinsonian Disorders::Parkinson Disease
dc.subject
NAMED GROUPS::Persons::Caregivers
dc.subject
ANTHROPOLOGY, EDUCATION, SOCIOLOGY, AND SOCIAL PHENOMENA::Social Sciences::Quality of Life
dc.subject
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos::enfermedad de Parkinson
dc.subject
DENOMINACIONES DE GRUPOS::personas::cuidadores de pacientes
dc.subject
ANTROPOLOGÍA, EDUCACIÓN, SOCIOLOGÍA Y FENÓMENOS SOCIALES::ciencias sociales::calidad de vida
dc.title
Staging Parkinson’s disease according to the MNCD classification correlates with caregiver burden
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
