Sistema de Salut de Catalunya
[Fernández-Cidón B] Bioquímica Especial y Biología Molecular, Laboratori Clínic, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Spain. [Candás-Estébanez B] Bioquímica Especial y Biología Molecular, Laboratori Clínic, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Spain. Clinical Laboratory, SCIAS-Hospital de Barcelona, Barcelona, Spain. [Gil-Serret M] Biosfer Teslab, Reus, Spain. [Amigó N] Biosfer Teslab, Reus, Spain. CIBERDEM, Universidad Rovira i Virgili, Tarragona, Spain. [Corbella E] Unidad de Lípidos y Riesgo Vascular, Servicio de Medicina Interna, Hospital Universitario de Bellvitge-IDIBELL, Barcelona, Spain. Centro de Investigación Biomédica en Red, Fisiopatologia de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain. [Rodríguez-Sánchez MA] Unidad de Lípidos y Riesgo Vascular, Servicio de Medicina Interna, Hospital Universitario de Bellvitge, Barcelona, Spain. [Mauri M] Servei de Medicina Interna, Hospital de Terrassa, Consorci Sanitari de Terrassa, Terrassa, Spain
Consorci Sanitari de Terrassa
2023-09-29T11:45:37Z
2023-09-29T11:45:37Z
2021-03-29
Cardiovascular diseases; Lipoproteins; Magnetic resonance spectroscopy
Enfermedades cardiovasculares; Lipoproteínas; Espectroscopia de resonancia magnética
Malalties cardiovasculars; Lipoproteïnes; Espectroscòpia de ressonància magnètica
Some lipoprotein disorders related to the residual risk of premature cardiovascular disease (PCVD) are not detected by the conventional lipid profile. In this case-control study, the predictive power of PCVD of serum sdLDL-C, measured using a lipoprotein precipitation method, and of the physicochemical properties of serum lipoproteins, analyzed by nuclear magnetic resonance (NMR) techniques, were evaluated. We studied a group of patients with a first PCVD event (n = 125) and a group of control subjects (n = 190). Conventional lipid profile, the size and number of Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), High Density Lipoproteins (HDL) particles, and the number of particles of their subclasses (large, medium, and small) were measured. Compared to controls, PCVD patients had lower concentrations of all LDL particles, and smaller and larger diameter of LDL and HDL particles, respectively. PCVD patients also showed higher concentrations of small dense LDL-cholesterol (sdLDL), and triglycerides (Tg) in LDL and HDL particles (HDL-Tg), and higher concentrations of large VLDL particles. Multivariate logistic regression showed that sdLDL-C, HDL-Tg, and large concentrations of LDL particles were the most powerful predictors of PCVD. A strong relationship was observed between increased HDL-Tg concentrations and PCVD. This study demonstrates that beyond the conventional lipid profile, PCVD patients have other atherogenic lipoprotein alterations that are detected by magnetic resonance imaging (MRI) analysis.
This work was supported in part by the Spanish Ministry of Health (Carlos III Health Institute) through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund, funded by the following grant codes: PI16/01094 and PI19/01032.
Article
Published version
English
Sistema cardiovascular - Malalties; Lipoproteïnes; Espectroscòpia de ressonància magnètica nuclear; DISEASES::Cardiovascular Diseases; CHEMICALS AND DRUGS::Lipids::Lipoproteins; ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Chemistry Techniques, Analytical::Spectrum Analysis::Magnetic Resonance Spectroscopy; ENFERMEDADES::enfermedades cardiovasculares; COMPUESTOS QUÍMICOS Y DROGAS::lípidos::lipoproteínas; TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas de química analítica::análisis espectral::espectroscopia de resonancia magnética
MDPI
Journal of Clinical Medicine;10(7)
https://doi.org/10.3390/jcm10071379
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
