dc.contributor
Institut Català de la Salut
dc.contributor
[Czajka-Francuz P, Mankan A] Fortrea, Inc., Durham, NC, United States. [Prendes MJ, Pabla S, Ramkissoon S] Labcorp Oncology, Durham, NC, United States. [Quintana Á, Peiró S] Breast Cancer Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Czajka-Francuz, Paulina
dc.contributor.author
Prendes, Maria J.
dc.contributor.author
Mankan, Arun K
dc.contributor.author
Pabla, Sarabjot
dc.contributor.author
Ramkissoon, Shakti
dc.contributor.author
Quintana, Angela
dc.contributor.author
Peiró, Sandra
dc.date.accessioned
2025-10-25T05:38:26Z
dc.date.available
2025-10-25T05:38:26Z
dc.date.issued
2023-08-14T11:55:20Z
dc.date.issued
2023-08-14T11:55:20Z
dc.date.issued
2023-06-22
dc.identifier
Czajka-Francuz P, Prendes MJ, Mankan A, Quintana Á, Pabla S, Ramkissoon S, et al. Mechanisms of immune modulation in the tumor microenvironment and implications for targeted therapy. Front Oncol. 2023 Jun 22;13:1200646.
dc.identifier
https://hdl.handle.net/11351/10088
dc.identifier
10.3389/fonc.2023.1200646
dc.identifier
001023052800001
dc.identifier.uri
http://hdl.handle.net/11351/10088
dc.description.abstract
Cancer; Immunosuppression mechanisms; Tumor microenvironment
dc.description.abstract
Cáncer; Mecanismos de inmunosupresión; Microambiente tumoral
dc.description.abstract
Càncer; Mecanismes d'immunosupressió; Microambient tumoral
dc.description.abstract
The efficacy of cancer therapies is limited to a great extent by immunosuppressive mechanisms within the tumor microenvironment (TME). Numerous immune escape mechanisms have been identified. These include not only processes associated with tumor, immune or stromal cells, but also humoral, metabolic, genetic and epigenetic factors within the TME. The identification of immune escape mechanisms has enabled the development of small molecules, nanomedicines, immune checkpoint inhibitors, adoptive cell and epigenetic therapies that can reprogram the TME and shift the host immune response towards promoting an antitumor effect. These approaches have translated into series of breakthroughs in cancer therapies, some of which have already been implemented in clinical practice. In the present article the authors provide an overview of some of the most important mechanisms of immunosuppression within the TME and the implications for targeted therapies against different cancers.
dc.format
application/pdf
dc.publisher
Frontiers Media
dc.relation
Frontiers in Oncology;13
dc.relation
https://doi.org/10.3389/fonc.2023.1200646
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Càncer - Immunoteràpia
dc.subject
DISEASES::Neoplasms
dc.subject
Other subheadings::Other subheadings::Other subheadings::/drug therapy
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy
dc.subject
ENFERMEDADES::neoplasias
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia
dc.title
Mechanisms of immune modulation in the tumor microenvironment and implications for targeted therapy
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
