dc.contributor.author |
Pérez-Holanda Fernández, Sergio |
dc.contributor.author |
Rodrigo, Luis |
dc.contributor.author |
Piñol Felis, Carme |
dc.contributor.author |
Viñas Salas, Joan |
dc.date |
2010-04-22T07:16:10Z |
dc.date |
2010-04-22T07:16:10Z |
dc.date |
2008 |
dc.identifier |
1471-2407 |
dc.identifier |
http://hdl.handle.net/10459.1/345 |
dc.identifier |
https://doi.org/10.1186%2F1471-2407-8-217 |
dc.identifier.uri |
http://hdl.handle.net/10459.1/345 |
dc.description |
Background
To examine the effect of anastomosis on experimental carcinogenesis in the colon of rats.
Methods
Forty-three 10-week-old male and female Sprague-Dawley rats were operated on by performing an end-to-side ileorectostomy. Group A:16 rats received no treatment. Group B: 27 rats received 18 subcutaneous injections weekly at a dose of 21 mg/kg wt of 1–2 dimethylhydrazine (DMH), from the eighth day after the intervention. Animals were sacrificed between 25–27 weeks. The number of tumours, their localization, size and microscopic characteristics were recorded. A paired chi-squared analysis was performed comparing tumoral induction in the perianastomotic zone with the rest of colon with faeces.
Results
No tumours appeared in the dimethylhydrazine-free group. The percentage tumoral area was greater in the perianastomotic zone compared to tumours which had developed in the rest of colon with faeces (p = 0.014).
Conclusion
We found a cocarcinogenic effect due to the creation of an anastomosis, when using an experimental model of colonic carcinogenesis induced by DMH in rats. |
dc.language |
eng |
dc.publisher |
BioMed Central |
dc.relation |
Reproducció del document publicat a https://doi.org/10.1186%2F1471-2407-8-217 |
dc.relation |
BMC Cancer, 2008, vol. 8, núm. 217, p.1-6 |
dc.rights |
cc-by, (c) Pérez-Holanda et al., 2008 |
dc.rights |
http://creativecommons.org/licenses/by/2.0/es/deed.ca |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Recte--Càncer |
dc.subject |
Carcinogènesi |
dc.title |
Colonic perianastomotic carcinogenesis in an experimental model |
dc.type |
article |
dc.type |
publishedVersion |