dc.contributor.author
Akhatova, Ayazhan
dc.contributor.author
Jones, Celine
dc.contributor.author
Coward, Kevin
dc.contributor.author
Yeste Oliveras, Marc
dc.date.accessioned
2025-02-28T10:20:29Z
dc.date.available
2025-02-28T10:20:29Z
dc.date.issued
2025-01-16
dc.identifier
http://hdl.handle.net/10256/26475
dc.identifier
PMC11740528
dc.identifier.uri
https://hdl.handle.net/10256/26475
dc.description.abstract
Recent studies support the influence of paternal lifestyle and diet before conception on the health of the offspring via epigenetic inheritance through sperm DNA methylation, histone modification, and small non-coding RNA (sncRNA) expression and regulation. Smoking may induce DNA hypermethylation in genes related to anti-oxidation and insulin resistance. Paternal diet and obesity are associated with greater risks of metabolic dysfunction in offspring via epigenetic alterations in the sperm. Metabolic changes, such as high blood glucose levels and increased body weight, are commonly observed in the offspring of fathers subjected to chronic stress, in addition to an enhanced risk of depressive-like behaviour and increased sensitivity to stress in both the F0 and F1 generations. DNA methylation is correlated with alterations in sperm quality and the ability to fertilise oocytes, possibly via a differentially regulated MAKP81IP3 signalling pathway. Paternal exposure to toxic endocrine-disrupting chemicals (EDCs) is also linked to the transgenerational transmission of increased predisposition to disease, infertility, testicular disorders, obesity, and polycystic ovarian syndrome (PCOS) in females through epigenetic changes during gametogenesis. As the success of assisted reproductive technology (ART) is also affected by paternal diet, BMI, and alcohol consumption, its outcomes could be improved by modifying factors that are dependent on male lifestyle choices and environmental factors. This review discusses the importance of epigenetic signatures in sperm including DNA methylation, histone retention, and sncRNA for sperm functionality, early embryo development, and offspring health. We also discuss the mechanisms by which paternal lifestyle and environmental factors (obesity, smoking, EDCs, and stress) may impact the sperm epigenome
dc.description.abstract
The authors acknowledge the support from the Regional Government of Catalonia, Spain (2021-SGR-00900), and the Catalan Institution for Research and Advanced Studies (ICREA)
dc.format
application/pdf
dc.relation
info:eu-repo/semantics/altIdentifier/doi/10.1186/s13148-025-01815-1
dc.relation
info:eu-repo/semantics/altIdentifier/issn/1868-7083
dc.rights
Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacional
dc.rights
http://creativecommons.org/licenses/by-nc-nd/4.0
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Clinical Epigenetics, 2025, vol. 17, art.núm. 7, p. 7.1-7.25
dc.source
Articles publicats (D-B)
dc.source
Akhatova, Ayazhan Jones, Celine Coward, Kevin Yeste Oliveras, Marc 2025 How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development and offspring health Clinical Epigenetics 17 art.núm. 7 7.1 7.25
dc.subject
Embriologia humana
dc.subject
Fecunditat humana
dc.subject
Reproducció humana
dc.subject
Human embryology
dc.subject
Human fertility
dc.subject
Human reproduction
dc.title
How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development and offspring health
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
