dc.contributor
Agencia Estatal de Investigación
dc.contributor.author
Vila-Solés, Laia
dc.contributor.author
García-Brito, Soleil
dc.contributor.author
Aldavert Vera, Laura
dc.contributor.author
Kádár García, Elisabeth
dc.contributor.author
Huguet i Blanco, Gemma
dc.contributor.author
Morgado-Bernal, Ignacio
dc.contributor.author
Segura Torres, Pilar
dc.date.accessioned
2024-10-29T23:08:14Z
dc.date.available
2024-10-29T23:08:14Z
dc.date.issued
2022-12-15
dc.identifier
http://hdl.handle.net/10256/25126
dc.identifier.uri
https://hdl.handle.net/10256/25126
dc.description.abstract
Intracranial electrical self-stimulation (ICSS) is a useful procedure in animal research. This form of administration ensures that areas of the brain reward system (BRS) are being functionally activated, since the animals must perform an operant response to self-administer an electrical stimulus. Rewarding post-training ICSS of the medial forebrain bundle (MFB), an important system of the BRS, has been shown to consistently improve rats’ acquisition and retention in several learning tasks. In the clinical setting, deep brain stimulation (DBS) of different targets is currently being used to palliate the memory impairment that occurs in some neurodegenerative diseases. However, the stimulation of the MFB has only been used to treat emotional alterations, not memory disorders. Since DBS stimulation treatments in humans are exclusively administered by external sources, studies comparing the efficacy of that form of application to a self-administered stimulation are key to the translationality of ICSS. This protocol compares self-administered (ICSS) and experimenter-administered (EAS) stimulation of the MFB on the spatial Morris Water Maze task (MWM). c-Fos immunohistochemistry procedure was carried out to evaluate neural activation after retention. Results show that the stimulation of the MFB improves the MWM task regardless of the form of administration, although some differences in c-Fos expression were found. Present results suggest that MFB-ICSS is a valid animal model to study the effects of MFB electrical stimulation on memory, which could guide clinical applications of DBS. The present protocol is a useful guide for establishing ICSS behavior in rats, which could be used as a learning and memory-modulating treatment.
dc.description.abstract
This work was supported by PID2020-117101RB-C21 and PID2020-117101RB-C22 grants from Ministerio de Ciencia e Innovación (Spain)
dc.format
application/pdf
dc.publisher
Frontiers Media
dc.relation
info:eu-repo/semantics/altIdentifier/doi/10.3389/fnbeh.2022.1046259
dc.relation
info:eu-repo/semantics/altIdentifier/eissn/1662-5153
dc.relation
PID2020-117101RB-C22
dc.relation
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117101RB-C22/ES/ESTIMULACION ELECTRICA REFORZANTE COMO TRATAMIENTO PROTECTOR DEL DETERIORO COGNITIVO EN ENFERMEDAD DE ALZHEIMER: BIOMARCADORES Y VERIFICACION EN MUESTRAS DE PACIENTES/
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Frontiers in Behavioral Neuroscience, 2022, vol. 16, art. núm. 1046259
dc.source
Articles publicats (D-B)
dc.subject
Memòria -- Aspectes fisiològics
dc.subject
Memory -- Physiological aspects
dc.subject
Alzheimer, Malaltia d'
dc.subject
Alzheimer's disease
dc.subject
Cervell -- Estimulació
dc.subject
Brain stimulation
dc.title
Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment: Comparison between self-administration and experimenter-administration
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
