dc.contributor
Ministerio de Ciencia e Innovación (Espanya)
dc.contributor.author
Ribó i Panosa, Marc
dc.contributor.author
Benito i Mundet, Antoni
dc.contributor.author
Vilanova i Brugués, Maria
dc.date.issued
2011-07-12
dc.identifier
http://hdl.handle.net/10256/16188
dc.identifier
978-3-642-21078-5
dc.description.abstract
Ribonucleases are small basic proteins that have shown remarkable antitumor activity linked to their ability to destroy RNA. Therefore, they are a second line of cancer chemotherapeutics as they are not genotoxic. This chapter summarizes the main biochemical characteristics of these enzymes and the key factors responsible for their cytotoxic mechanism. Some of them are shared by most cytotoxins, but each RNase has particular cancer cell killing abilities. The effects on the cell cycle and the induced apoptosis mechanism are cell dependent. The knowledge obtained from the cytotoxic mechanism of natural cytotoxic RNases has been used to artificially engineer more potent and selective RNA-degrading enzymes. These approaches are also described. The chapter ends with a brief description of the results of the clinical trials performed with RNases
dc.description.abstract
This work has been supported by grants BFU2009-06935 from MICINN (Spain) and GRCT04 from the University of Girona
dc.format
application/pdf
dc.relation
info:eu-repo/semantics/altIdentifier/doi/10.1007/978-3-642-21078-5_3
dc.relation
info:eu-repo/semantics/altIdentifier/isbn/978-3-642-21077-8
dc.relation
info:eu-repo/grantAgreement/MICINN//BFU2009-06935/ES/Bases Moleculares Del Plegamiento Y Citotoxicidad De Las Ribonucleasas Pancreaticas. Evaluacion De La Actividad Citotoxica Y Diseño De Estrategias Para Su Control Mediante Splicing Proteico./
dc.rights
Tots els drets reservats
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Nicholson, Allen W.(eds). Ribonucleases. (Nucleic Acids and Molecular Biology, núm. 26). DOI https://doi.org/10.1007/978-3-642-21078-5, p.55-88
dc.source
Llibres / Capítols de LLibre (D-B)
dc.subject
Enginyeria de proteïnes
dc.subject
Protein engineering
dc.subject
Càncer -- Tractament
dc.subject
Cancer -- Treatment
dc.title
Antitumor Ribonucleases
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:eu-repo/semantics/acceptedVersion
