Title:
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Collective dynamics of interacting molecular motors
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Author:
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Campàs, O.; Kafri, Y.; Zeldovich, K.; Casademunt i Viader, Jaume; Joanny, J.-F.
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Other authors:
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Universitat de Barcelona |
Abstract:
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The collective dynamics of N interacting processive molecular motors are considered theoretically when an external force is applied to the leading motor. We show, using a discrete lattice model, that the force-velocity curves strongly depend on the effective dynamic interactions between motors and differ significantly from those of a simple approach where the motors equally share the force. Moreover, they become essentially independent of the number of motors if N is large enough (N * 5 for conventional kinesin). We show that a two-state ratchet model has a very similar behavior to that of the coarse-grained lattice model with effective interactions. The general picture is unaffected by motor attachment and detachment events. |
Subject(s):
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-Dinàmica molecular -Molecular dynamics |
Rights:
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(c) American Physical Society, 2006
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Document type:
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Article Article - Published version |
Published by:
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American Physical Society
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