Título:
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Auditory Target and Novelty Processing in Patients with Unilateral Hippocampal Sclerosis: A Current-Source Density Study
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Autor/a:
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Vilà Balló, Adrià; François, Clément; Cucurell, David; Miró, Júlia; Falip, Mercè; Juncadella, Montserrat; Rodríguez Fornells, Antoni
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Abstract:
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The capacity to respond to novel events is crucial for adapting to the constantly changing environment.
Here, we recorded 29-channel Event Related Brain Potentials (ERPs) during an active auditory novelty
oddball paradigm and used for the first time Current Source Density-transformed Event Related Brain
Potentials and associated time-frequency spectra to study target and novelty processing in a group of
epileptic patients with unilateral damage of the hippocampus (N = 18) and in healthy matched control
participants (N = 18). Importantly, we used Voxel-Based Morphometry to ensure that our group of
patients had a focal unilateral damage restricted to the hippocampus and especially its medial part.
We found a clear deficit for target processing at the behavioral level. In addition, compared to controls,
our group of patients presented (i) a reduction of theta event-related synchronization (ERS) for targets
and (ii) a reduction and delayed P3a source accompanied by reduced theta and low-beta ERS and alpha
event-related synchronization (ERD) for novel stimuli. These results suggest that the integrity of the
hippocampus might be crucial for the functioning of the complex cortico-subcortical network involved
in the detection of novel and target stimuli |
Materia(s):
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-Hipocamp -Hippocampus (Brain) |
Derechos:
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Attribution 3.0 Spain
http://creativecommons.org/licenses/by/3.0/es/ |
Tipo de documento:
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Artículo Artículo - Versión publicada |
Editor:
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Nature Publishing Group
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Compartir:
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