The myxobacterial metabolite soraphen A inhibits HIV-1 by reducing virus production and altering virion composition

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dc.contributor.author	Fleta Soriano, Eric, 1983-
dc.contributor.author	Smutna, Katarína
dc.contributor.author	Martinez, Javier P.
dc.contributor.author	Lorca Oró, Cristina
dc.contributor.author	Sadiq, S. Kashif
dc.contributor.author	Mirambeau, Gilles
dc.contributor.author	Lopez-Iglesias, Carmen
dc.contributor.author	Bosch, Marta
dc.contributor.author	Pol, Albert
dc.contributor.author	Brönstrup, Mark
dc.contributor.author	Díez Antón, Juana, 1962-
dc.contributor.author	Meyerhans, Andreas
dc.date	2017
dc.identifier.citation	Fleta-Soriano E, Smutná K, Martínez JP, Lorca Oró C, Sadiq SK, Mirambeau G et al. The myxobacterial metabolite soraphen A inhibits HIV-1 by reducing virus production and altering virion composition. Antimicrob Agents Chemother. 2017 Jul 25; 61(8): e00739-17. DOI: 10.1128/AAC.00739-17
dc.identifier.citation	0066-4804
dc.identifier.citation	http://dx.doi.org/10.1128/AAC.00739-17
dc.identifier.uri	http://hdl.handle.net/10230/32829
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	American Society for Microbiology
dc.relation	info:eu-repo/grantAgreement/ES/3PN/BES2011-048569
dc.relation	info:eu-repo/grantAgreement/ES/1PE/SAF2013-46077
dc.relation	info:eu-repo/grantAgreement/ES/1PE/SAF2016-75505-R
dc.relation	info:eu-repo/grantAgreement/ES/1PE/BFU2016-80039-R
dc.rights	© American Society for Microbiology
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	Virus
dc.subject	Medicaments antivírics
dc.subject	VIH (Virus)
dc.title	The myxobacterial metabolite soraphen A inhibits HIV-1 by reducing virus production and altering virion composition
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion
dc.description.abstract	Soraphen A is a myxobacterial metabolite that blocks the acetyl-coenzyme A carboxylase of the host and was previously identified as a novel HIV inhibitor. Here, we report that soraphen A acts by reducing virus production and altering the gp120 virion content, impacting entry capacity and infectivity. These effects are partially reversed by addition of palmitic acid, suggesting that inhibition of HIV envelope palmitoylation is one of the mechanisms of antiviral action.
dc.description.abstract	The research was funded by the German Centre for Infection Research (DZIF), Spanish Ministry of Economy, Industry and Competitiveness and FEDER BES-2011-048569, Spanish Ministry of Economy, Industry and Competitiveness and FEDER SAF2013-46077-R SAF2016-75505-R, the Spanish Ministry of Economy, Industry and Competitiveness and FEDER BFU2016-80039-R and the Maria de Maetzu Programme for Units of Excellence in R&DMDM-2014-0370

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