A Synthetic Strategy for Conjugation of Paromomycin to Cell-Penetrating Tat(48-60) for Delivery and Visualization into Leishmania Parasites

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dc.contributor.author	Defaus, Sira
dc.contributor.author	Gallo, Maria
dc.contributor.author	Abengózar, María A.
dc.contributor.author	Rivas, Luis
dc.contributor.author	Andreu Martínez, David
dc.date	2017
dc.identifier.citation	Defaus S, Gallo M, Abengózar MA, Rivas L, Andreu Martínez D. A Synthetic Strategy for Conjugation of Paromomycin to Cell-Penetrating Tat(48-60) for Delivery and Visualization into Leishmania Parasites. International Journal of Peptides. 2017; 2017: 4213037. DOI: 10.1155/2017/4213037
dc.identifier.citation	http://dx.doi.org/10.1155/2017/4213037
dc.identifier.uri	http://hdl.handle.net/10230/32170
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Hindawi
dc.relation	International Journal of Peptides. 2017; 2017: 4213037
dc.relation	info:eu-repo/grantAgreement/ES/3PN/SAF2011-24899
dc.relation	info:eu-repo/grantAgreement/ES/1PE/AGL2014-52395-C2-2-R
dc.rights	Copyright © 2017 Sira Defaus et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights	https://creativecommons.org/licenses/by/4.0/
dc.rights	info:eu-repo/semantics/openAccess
dc.title	A Synthetic Strategy for Conjugation of Paromomycin to Cell-Penetrating Tat(48-60) for Delivery and Visualization into Leishmania Parasites
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	A successful approach to deliver paromomycin, a poorly absorbed aminoglycoside antibiotic, to parasite cells is reported, based on selective protection of amino and hydroxyl groups followed by conjugation to a fluorolabeled, PEG-functionalized cell-penetrating Tat(48-60) peptide. The resulting construct is efficiently internalized into Leishmania cells, evidencing the fitness of cell-penetrating peptides as vectors for efficiently transporting low-bioavailability drugs into cells.
dc.description.abstract	Work at Pompeu Fabra University was supported by Grants SAF2011-24899 and AGL2014-52395-C2-2-R from the Spanish Ministry of Economy and Competiveness (MINECO) to David Andreu; work at the Centro de Investigaciones Biológicas was supported by Grants PI12-02706 from ISCIII-FEDER, SAF2015-65740-R from MINECO to Luis Rivas, and RICET RD12/0018/0007 and RD16/0027/0010-FEDER.

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