Title:
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Development of the adaptive NK cell response to human cytomegalovirus in the context ofaging
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Author:
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López-Botet, Miguel; Muntasell i Castellví, Aura, 1972-; Martínez-Rodriguez, José E.; López-Montañés, María; Costa-García, Marcel; Pupuleku, Aldi, 1985-
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Abstract:
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Human cytomegalovirus (HCMV) establishes a highly prevalent life-long latent infection. Though generally subclinical, HCMV infection may have severe consequences during fetal development and in immunocompromised individuals. Based on epidemiological studies HCMV(+) serology has been associated with the development of atherosclerosis, immune senescence and an increase mortality rate in elderly people. Such long-term detrimental effects of the viral infection presumably result from an inefficient immune control of the pathogen, depending on the quality and evolution of the individual host-pathogen relationship. Together with antigen-specific T lymphocytes, NK cells play an important role in anti-viral immune defense. HCMV promotes in some individuals the differentiation and persistent steady state expansion of an NK cell subset bearing the CD94/NKG2C activating receptor. The relationship between this adaptive NK cell response to HCMV and aging is overviewed. |
Abstract:
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The team is supported by grants from Plan Estatal I + D Retos (SAF2013-49063-C2-1-R, MINECO-FEDER), Fundació La Marató de TV3 (121531) and REEM (RD12/0032/0016, Instituto de Salud Carlos III). AM is supported by Asociación Espanola ˜ Contra el Cáncer (AECC). |
Subject(s):
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-Envelliment -- Aspectes immunològics -Citomegalovirus |
Rights:
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info:eu-repo/semantics/embargoedAccess
© Elsevier http://dx.doi.org/10.1016/j.mad.2016.06.010 |
Document type:
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Article Article - Accepted version |
Published by:
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Elsevier
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