Title:
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Role of PRC2-associated factors in stem cells and disease
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Author:
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Vizán, Pedro; Beringer, Malte; Ballaré, Cecilia Julia; Di Croce, Luciano
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Abstract:
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This work was supported by grants from the Spanish “Ministerio de Educación y Ciencia” (SAF2013-48926-P), from AGAUR, “Fundació a Marató” (20131110), and from the European Commission's 7th Framework Program 4DCellFate grant number 277899 to L.D.C |
Abstract:
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The Polycomb group (PcG) of proteins form chromatin-binding complexes with histone-modifying activity. The two main PcG repressive complexes studied (PRC1 and PRC2) are generally associated with chromatin in its repressed state. PRC2 is responsible for methylation of histone H3 at lysine 27 (H3K27me3), an epigenetic mark that is linked with numerous biological processes, including development, adult homeostasis and cancer. The core canonical complex PRC2, which contains the EZH1/2, SUZ12 and EED proteins, may be extended and functionally manipulated through interactions with several other proteins. In this review, we focus on these PRC2-associated proteins. As PRC2 functions are diverse, the variability conferred by these sub-stoichiometrically associated members may help to understand specific changes in PRC2 activity, chromatin recruitment and distribution required for gene repression. |
Subject(s):
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-Cèl·lules mare -AEBP2 -C17orf96 -JARID2 -RBAP46/48 -Chromatin -Epigenetics -Gene expression -Polycomb -Polycomb-like -Stem cells |
Rights:
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This is the pre-peer reviewed version of the following article: Vizán P, Beringer M, Ballaré C, Di Croce L. Role of PRC2-associated factors in stem cells and disease. FEBS Journal. 2015; 282(9): 1723-1735. DOI 10.1111/febs.13083, which has been published in final form at http://dx.doi.org/10.1111/febs.13083. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Document type:
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Article Article - Accepted version |
Published by:
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Wiley-Blackwell
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