Autor/a:
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Loomis, Dana; Guha, Neela; Kogevinas, Manolis; Fontana, Vincenzo; Gennaro, Valerio; Kolstad, Henrik A.; McElvenny, Damien Martin; Sallmen, Markku; Saracci, Rodolfo
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Abstract:
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OBJECTIVE: To investigate the carcinogenicity of styrene by
reanalysing data from a previous international cohort study of
workers in the reinforced plastics industry. METHODS: Mortality
from cancers of prior interest was analysed with more detailed
consideration of exposure-response relations and an updated
classification of leukaemias and lymphomas in data from a
previous international cohort study of 37 021 reinforced
plastics workers exposed to airborne styrene. RESULTS: Increased
mortality from non-Hodgkin's lymphoma (NHL) was associated with
the mean level of exposure to styrene in air (relative risk (RR)
2.31, 95% CI 1.29 to 4.12 per 100 ppm), but not with cumulative
styrene exposure. Similar associations with mean exposure were
observed for the oesophagus (RR 2.44, 95% CI 1.11 to 5.36 per
100 ppm) and pancreas (RR 1.89, 95% CI 1.17 to 3.09).
Oesophageal cancer mortality was also associated with cumulative
styrene exposure lagged 20 years (RR 1.16, 95% CI 1.03 to 1.31).
No other cancer, including lung cancer, was associated with any
indicator of styrene exposure. CONCLUSION: This reanalysis does
not substantially change the conclusions of the original study
with respect to NHL or lung cancer but new evidence concerning
cancers of the oesophagus and pancreas merits further
investigation. |