Title:
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Maternal Smoking during Pregnancy and Early Childhood and
Development of Asthma and Rhinoconjunctivitis - a MeDALL Project
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Author:
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Thacher, Jesse D.; Gehring, Ulrike; Gruzieva, Olena; Standl, Marie; Pershagen, Göran; Bauer, Carl-Peter; Berdel, Dietrich; Keller, Theresa; Koletzko, Sibylle; Koppelman, Gerard H.; Kull, Inger; Lau, Susanne; Lehmann, Irina; Maier, Dieter; Schikowski, Tamara; Wahn, Ulrich; Wijga, Alet H.; Heinrich, Joachim; Bousquet, Jean; Antó i Boqué, Josep Maria; Berg, Andrea von; Melén, Erik; Smit, Henriette A.; Keil, Thomas; Bergstrom, Anna
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Abstract:
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BACKGROUND: The role of tobacco smoke exposure in the
development and persistence of asthma and rhinoconjunctivitis
through childhood into adolescence is unclear. OBJECTIVES: We
assessed the associations of parental smoking from fetal life
through adolescence with asthma and rhinoconjunctivitis during
childhood and adolescence. METHODS: We analyzed data for 10,860
participants of five European birth cohort studies from the
Mechanisms of the Development of Allergy (MeDALL) consortium.
Parental smoking habits and health outcomes (early transient,
persistent, and adolescent-onset asthma and rhinoconjunctivitis)
were based on questionnaires covering the period from pregnancy
to 14-16 y of age. Data were combined and analyzed using a
one-stage and two-stage individual participant data
meta-analysis. RESULTS: Overall, any maternal smoking during
pregnancy tended to be associated with an increased odds of
prevalent asthma [adjusted odds ratio (aOR)=1.19 (95% CI: 0.98,
1.43)], but not prevalent rhinoconjunctivitis [aOR=1.05 (95% CI:
0.90, 1.22)], during childhood and adolescence. In analyses with
phenotypes related to age of onset and persistence of disease,
any maternal smoking during pregnancy was associated with early
transient asthma [aOR=1.79 (95% CI: 1.14, 2.83)]. Maternal
smoking of >/=10 cigarettes/day during pregnancy was
associated with persistent asthma [aOR=1.66 (95% CI: 1.29,
2.15)] and persistent rhinoconjunctivitis [aOR=1.55 (95% CI,
1.09, 2.20)]. Tobacco smoke exposure during fetal life, infancy,
childhood, and adolescence was not associated with
adolescent-onset asthma or rhinoconjunctivitis. CONCLUSIONS:
Findings from this combined analysis of five European birth
cohorts strengthen evidence linking early exposure to tobacco
smoke with asthma during childhood and adolescence. Children
with high early-life exposure were more likely than unexposed
children to have early transient and persistent asthma and
persistent rhinoconjunctivitis. https://doi.org/10.1289/EHP2738. |
Subject(s):
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-Embarassades -Hàbit de fumar en l'embaràs -Pregnant women -Pregnant women Tobacco use |
Rights:
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Domini públic / Public domain
http://creativecommons.org/publicdomain/mark/1.0/ |
Document type:
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Article Article - Published version |
Published by:
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National Institute of Environmental Health Sciences
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