Healthcare professionals working with cancer patients have considerable risk for burnout. Nevertheless we know not enough about the burnout prevalence in oncological healthcare in Spain. This study aimed at estimating burnout levels of oncology professionals and at assessing satisfaction and work difficulties. 115 professionals answered the Maslach Burnout Inventory, a satisfaction questionnaire, and questions about difficulties and improvements. Results revealed a considerable number of professionals with burnout showing physicians a higher level than nurses. Burnout was negatively related to aspects of work satisfaction. Difficulties were work overload, communication and emotional aspects with patients and colleagues. Improvements dealt with organizational and individual aspects. Results are useful for prevention and intervention programs. Future research should analyze the work situation and personal factors.