Título:
|
Sustained malaria control over an eight-year period in Papua New
Guinea: the challenge of low-density asymptomatic infections
|
Autor/a:
|
Koepfli, Cristian; Ome-Kaius, Maria; Jally, Shadrach; Malau, Elisheba; Maripal, Samuel; Ginny, Jason; Timinao, Lincoln; Kattenberg, Johanna Helena; Obadia, Thomas; White, Michael T.; Rarau, Patricia; Senn, Nicolas; Barry, Alyssa E.; Kazura, James W.; Mueller, Ivo; Robinson, Leanne J.
|
Abstract:
|
Background: The scale-up of effective malaria control in the
last decade has resulted in a substantial decline in the
incidence of clinical malaria in many countries. The effects on
the proportions of asymptomatic and submicroscopic infections,
and on transmission potential are yet poorly understood.
Methods: In Papua New Guinea, vector control has been
intensified since 2008, and improved diagnosis and treatment
introduced in 2012. Cross-sectional surveys were conducted in
Madang Province in 2006 (n=1280), 2010 (n=2117) and 2014
(n=2516). Infections were quantified by highly sensitive qPCR
and gametocytes by RT-qPCR. Results: P. falciparum prevalence by
qPCR decreased from 42% in 2006 to 9% in 2014. P. vivax
prevalence decreased from 42% in 2006 to 13% in 2010, but then
increased to 20% in 2014. Parasite densities decreased 5-fold
from 2006 to 2010; 72% of P. falciparum and 87% of P. vivax
infections were submicroscopic in 2014. Gametocyte density and
positivity correlated closely with parasitemia, and population
gametocyte prevalence decreased 3-fold for P. falciparum and 29%
for P. vivax from 2010 to 2014. Conclusions: Sustained control
has resulted in reduced transmission potential but an increasing
proportion of gametocyte carriers are asymptomatic and
submicroscopic and represent a challenge to malaria control. |
Materia(s):
|
-Malària -Papua Nova Guinea -Malaria -Papua New Guinea |
Derechos:
|
cc by-nc-nd (c) Koepfli et al., 2017
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Tipo de documento:
|
Artículo Artículo - Versión publicada |
Editor:
|
Oxford University Press
|
Compartir:
|
|