The effectiveness of influenza vaccination in the elderly in Spain in two influenza seasons: a multicenter case-control study

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dc.contributor	Universitat de Barcelona
dc.contributor.author	Domínguez García, Àngela
dc.contributor.author	Soldevila, Núria
dc.contributor.author	Toledo, Diana
dc.contributor.author	Godoy, Pere
dc.contributor.author	Espejo, Elena
dc.contributor.author	Fernández, M.A.
dc.contributor.author	Mayoral, J.M.
dc.contributor.author	Castilla, Jesús
dc.contributor.author	Egurrola, Mikel
dc.contributor.author	Tamames, Sonia
dc.contributor.author	Astray, Jenaro
dc.contributor.author	Morales-Suárez-Varela, M.
dc.contributor.author	Torner Gràcia, Núria
dc.date	2017-10-17T17:51:36Z
dc.date	2017-10-17T17:51:36Z
dc.date	2017-08-24
dc.date	2017-10-17T17:51:36Z
dc.identifier.citation	1560-7917
dc.identifier.citation	670663
dc.identifier.uri	http://hdl.handle.net/2445/116702
dc.format	8 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	European Centre for Disease Prevention and Control (ECDC)
dc.relation	Reproducció del document publicat a: https://doi.org/10.2807/1560-7917.ES.2017.22.34.30602
dc.relation	Eurosurveillance, 2017, vol. 22, num. 34, p. 30602
dc.relation	https://doi.org/10.2807/1560-7917.ES.2017.22.34.30602
dc.rights	cc-by (c) Domínguez García, Àngela et al., 2017
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.subject	Grip
dc.subject	Vacunació
dc.subject	Persones grans
dc.subject	Espanya
dc.subject	Influenza
dc.subject	Vaccination
dc.subject	Older people
dc.subject	Spain
dc.title	The effectiveness of influenza vaccination in the elderly in Spain in two influenza seasons: a multicenter case-control study
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Influenza vaccination may limit the impact of influenza in the community. The aim of this study was to assess the effectiveness of influenza vaccination in preventing hospitalisation in individuals aged ≥ 65 years in Spain. A multicentre case-control study was conducted in 20 Spanish hospitals during 2013/14 and 2014/15. Patients aged ≥ 65 years who were hospitalised with laboratory-confirmed influenza were matched with controls according to sex, age and date of hospitalisation. Adjusted vaccine effectiveness (VE) was calculated by multivariate conditional logistic regression. A total of 728 cases and 1,826 matched controls were included in the study. Overall VE was 36% (95% confidence interval (CI): 22-47). VE was 51% (95% CI: 15-71) in patients without high-risk medical conditions and 30% (95% CI: 14-44) in patients with them. VE was 39% (95% CI: 20-53) in patients aged 65-79 years and 34% (95% CI: 11-51) in patients aged ≥ 80 years, and was greater against the influenza A(H1N1)pdm09 subtype than the A(H3N2) subtype. Influenza vaccination was effective in preventing hospitalisations of elderly individuals.

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