Title:
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Lifetime occupational exposure to metals and welding fumes, and
risk of glioma: a 7-country population-based case-control study
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Author:
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Parent, Marie-Elise; Turner, Michelle C.; Lavoue, Jérôme; Richard, Hugues; Figuerola, Jordi; Kincl, Laurel; Richardson, Lesley; Benke, Geza; Blettner, Maria; Fleming, Sarah; Hours, Martine; Krewski, Daniel; McLean, David; Sadetzki, Siegal; Schlaefer, Klaus; Schlehofer, Brigitte; Schuz, Joachim; Siemiatycki, Jack; van Tongeren, Martie; Cardis, Elisabeth
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Abstract:
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BACKGROUND: Brain tumor etiology is poorly understood. Based on
their ability to pass through the blood-brain barrier, it has
been hypothesized that exposure to metals may increase the risk
of brain cancer. Results from the few epidemiological studies on
this issue are limited and inconsistent. METHODS: We
investigated the relationship between glioma risk and
occupational exposure to five metals - lead, cadmium, nickel,
chromium and iron- as well as to welding fumes, using data from
the seven-country INTEROCC study. A total of 1800 incident
glioma cases and 5160 controls aged 30-69 years were included in
the analysis. Lifetime occupational exposure to the agents was
assessed using the INTEROCC JEM, a modified version of the
Finnish job exposure matrix FINJEM. RESULTS: In general, cases
had a slightly higher prevalence of exposure to the various
metals and welding fumes than did controls, with the prevalence
among ever exposed ranging between 1.7 and 2.2% for cadmium to
10.2 and 13.6% for iron among controls and cases, respectively.
However, in multivariable logistic regression analyses, there
was no association between ever exposure to any of the agents
and risk of glioma with odds ratios (95% confidence intervals)
ranging from 0.8 (0.7-1.0) for lead to 1.1 (0.7-1.6) for
cadmium. Results were consistent across models considering
cumulative exposure or duration, as well as in all sensitivity
analyses conducted. CONCLUSIONS: Findings from this large-scale
international study provide no evidence for an association
between occupational exposure to any of the metals under
scrutiny or welding fumes, and risk of glioma. |
Subject(s):
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-Glioma -Metalls -Glioma -Metals |
Rights:
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cc by (c) Parent et al., 2017
http://creativecommons.org/licenses/by/4.0/ |
Document type:
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Article Article - Published version |
Published by:
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BioMed Central
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