Título:
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Computational analysis of multimorbidity between asthma, eczema
and rhinitis
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Autor/a:
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Aguilar, Daniel; Pinart Gilberga, Mariona; Koppelman, Gerard H.; Saeys, Yvan; Nawijn, Martijn C.; Postma, Dirkje S.; Akdis, Mübeccel; Auffray, Charles; Ballereau, Stephane; Benet, Marta; Garcia-Aymerich, Judith; González, Juan Ramón; Guerra, Stefano; Keil, Thomas; Kogevinas, Manolis; Lambrecht, Bart; Lemonnier, Nathanael; Melén, Erik; Sunyer Deu, Jordi; Valenta, Rudolf; Valverde, Sergi; Wickman, Magnus; Bousquet, Jean; Oliva Miguel, Baldomero; Antó i Boqué, Josep Maria
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Abstract:
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BACKGROUND: The mechanisms explaining the co-existence of
asthma, eczema and rhinitis (allergic multimorbidity) are
largely unknown. We investigated the mechanisms underlying
multimorbidity between three main allergic diseases at a
molecular level by identifying the proteins and cellular
processes that are common to them. METHODS: An in silico study
based on computational analysis of the topology of the protein
interaction network was performed in order to characterize the
molecular mechanisms of multimorbidity of asthma, eczema and
rhinitis. As a first step, proteins associated to either disease
were identified using data mining approaches, and their overlap
was calculated. Secondly, a functional interaction network was
built, allowing to identify cellular pathways involved in
allergic multimorbidity. Finally, a network-based algorithm
generated a ranked list of newly predicted
multimorbidity-associated proteins. RESULTS: Asthma, eczema and
rhinitis shared a larger number of associated proteins than
expected by chance, and their associated proteins exhibited a
significant degree of interconnectedness in the interaction
network. There were 15 pathways involved in the multimorbidity
of asthma, eczema and rhinitis, including IL4 signaling and
GATA3-related pathways. A number of proteins potentially
associated to these multimorbidity processes were also obtained.
CONCLUSIONS: These results strongly support the existence of an
allergic multimorbidity cluster between asthma, eczema and
rhinitis, and suggest that type 2 signaling pathways represent a
relevant multimorbidity mechanism of allergic diseases.
Furthermore, we identified new candidates contributing to
multimorbidity that may assist in identifying new targets for
multimorbid allergic diseases. |
Materia(s):
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-Asma -Èczema -Rinitis -Immunologia -Asthma -Eczema -Rhinitis -Immunology |
Derechos:
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cc by (c) Aguilar et al., 2017
http://creativecommons.org/licenses/by/3.0/es/ |
Tipo de documento:
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Artículo Artículo - Versión publicada |
Editor:
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Public Library of Science
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