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| dc.contributor | Universitat de Barcelona |
|---|---|
| dc.contributor.author | Pinazo, María Jesús |
| dc.contributor.author | Posada, Elizabeth |
| dc.contributor.author | Izquierdo, Luis |
| dc.contributor.author | Tassies, Dolors |
| dc.contributor.author | Ferreira Marques, Alexandre |
| dc.contributor.author | Lazzari, Elisa de |
| dc.contributor.author | Aldasoro, Edelweiss |
| dc.contributor.author | Muñoz, José |
| dc.contributor.author | Abras Feliu, Alba |
| dc.contributor.author | Tebar, Silvia |
| dc.contributor.author | Gállego Culleré, M. (Montserrat) |
| dc.contributor.author | Almeida, Igor Correia de |
| dc.contributor.author | Reverter, Joan Carles |
| dc.contributor.author | Gascón i Brustenga, Joaquim |
| dc.date | 2017-06-06T11:07:18Z |
| dc.date | 2017-06-06T11:07:18Z |
| dc.date | 2016 |
| dc.date | 2017-06-06T11:07:18Z |
| dc.identifier.citation | 1935-2735 |
| dc.identifier.citation | 665580 |
| dc.identifier.uri | http://hdl.handle.net/2445/112005 |
| dc.description.abstract | Thromboembolic events were described in patients with Chagas disease without cardiomyopathy. We aim to confirm if there is a hypercoagulable state in these patients and to determine if there is an early normalization of hemostasis factors after antiparasitic treatment. Ninety-nine individuals from Chagas disease-endemic areas were classified in two groups: G1, with T.cruzi infection (n = 56); G2, healthy individuals (n = 43). Twenty-four hemostasis factors were measured at baseline. G1 patients treated with benznidazole were followed for 36 months, recording clinical parameters and performance of conventional serology, chemiluminescent enzyme-linked immunosorbent assay (trypomastigote-derived glycosylphosphatidylinositol-anchored mucins), quantitative polymerase chain reaction, and hemostasis tests every 6-month visits. Prothrombin fragment 1+2 (F1+2) and endogenous thrombin potential (ETP) were abnormally expressed in 77% and 50% of infected patients at baseline but returned to and remained at normal levels shortly after treatment in 76% and 96% of cases, respectively. Plasmin-antiplasmin complexes (PAP) were altered before treatment in 32% of G1 patients but normalized in 94% of cases several months after treatment. None of the patients with normal F1+2 values during follow-up had a positive qRT-PCR result, but 3/24 patients (13%) with normal ETP values did. In a percentage of chronic T. cruzi infected patients treated with benznidazole, altered coagulation markers returned into normal levels. F1+2, ETP and PAP could be useful markers for assessing sustained response to benznidazole. |
| dc.format | 14 p. |
| dc.format | application/pdf |
| dc.language.iso | eng |
| dc.publisher | Public Library of Science (PLoS) |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1371/journal.pntd.0004269 |
| dc.relation | PLoS Neglected Tropical Diseases, 2016, vol. 10, num. 1, p. e0004269 |
| dc.relation | https://doi.org/10.1371/journal.pntd.0004269 |
| dc.rights | cc-by (c) Pinazo, María Jesús et al., 2016 |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.subject | Hemostàsia |
| dc.subject | Malalties parasitàries |
| dc.subject | Malaltia de Chagas |
| dc.subject | Hemostasis |
| dc.subject | Parasitic diseases |
| dc.subject | Chagas' disease |
| dc.title | Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic. Response |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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