P-Stereogenic bisphosphines with a hydrazine backbone: from N-N atropoisomerism to double nitrogen inversion

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Título:	P-Stereogenic bisphosphines with a hydrazine backbone: from N-N atropoisomerism to double nitrogen inversion
Autor/a:	Prades, Amparo; Núñez-Pertíñez, Samuel; Riera i Escalé, Antoni; Verdaguer i Espaulella, Xavier
Otros autores:	Universitat de Barcelona
Abstract:	The synthesis of P-stereogenic bisphosphine ligands starting from a phosphinous acid chiral synthon and hydrazine is reported. The dialkylation of the hydrazine backbone yielded atropo- and nitrogeninversion isomers which are in slow exchange. The crystallization of one of the isomers allowed us to study the reaction kinetics of the equilibria. The new ligands were tested in the Rh catalysed asymmetric hydrogenation of various benchmark substrates attaining up to 99% ee.
Materia(s):	-Lligands -Catàlisi asimètrica -Ligands -Enantioselective catalysis
Derechos:	CC BY (c) Prades, Amparo et al., 2017 http://creativecommons.org/licenses/by/3.0/
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Royal Society of Chemistry
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Salomó, Ernest; Prades, Amparo; Riera i Escalé, Antoni; Verdaguer i Espaulella, Xavier

Salomó, Ernest; Prades, Amparo; Riera i Escalé, Antoni; Verdaguer i Espaulella, Xavier

Salomó, Ernest; Orgué Gassol, Sílvia; Riera i Escalé, Antoni; Verdaguer i Espaulella, Xavier

Orgué Gassol, Sílvia; Flores-Gaspar, Areli; Biosca, Maria; Pàmies, Oscar; Diéguez, Montserrat; Riera i Escalé, Antoni; Verdaguer i Espaulella, Xavier

Cabré, Albert; Verdaguer i Espaulella, Xavier; Riera i Escalé, Antoni

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