Combined treatment with environmental enrichment and (-)-epigallocatechin-3-gallate ameliorates learning deficits and hippocampal alterations in a mouse model of Down Syndrome

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dc.contributor	Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa
dc.contributor	Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica
dc.contributor.author	Catuara-Solarz, Silvina
dc.contributor.author	Espinoa Carrasco, Jose
dc.contributor.author	Erb, Ionas
dc.contributor.author	Langohr, Klaus
dc.contributor.author	González, Juan Ramon
dc.contributor.author	Notredame, Cedric
dc.contributor.author	Dierssen, Mara
dc.date	2016-11-08
dc.identifier.citation	Catuara-Solarz, S., Espinoa, J., Erb, I., Langohr, K., González, J., Notredame, C., Dierssen, M. Combined treatment with environmental enrichment and (-)-epigallocatechin-3-gallate ameliorates learning deficits and hippocampal alterations in a mouse model of Down Syndrome. "eNeuro", 8 Novembre 2016, vol. 3, núm. 5, p. 1-18.
dc.identifier.citation	2373-2822
dc.identifier.citation	10.1523/ENEURO.0103-16.2016
dc.identifier.uri	http://hdl.handle.net/2117/102765
dc.language.iso	eng
dc.relation	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099603/
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Àrees temàtiques de la UPC::Matemàtiques i estadística::Probabilitat
dc.subject	Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica::Anàlisi multivariant
dc.subject	Combinatorial probabilities
dc.subject	Multivariate analysis
dc.subject	Sampling (Statistics)
dc.subject	(-)-epigallocatechin-3-gallate
dc.subject	down Syndrome
dc.subject	Environmental Enrichment
dc.subject	Excitation-Inhibition Imbalance
dc.subject	neuroplasticity
dc.subject	Probabilitats
dc.subject	Anàlisi multivariable
dc.subject	Mostreig (Estadística)
dc.subject	Classificació AMS::60 Probability theory and stochastic processes::60C05 Combinatorial probability
dc.subject	Classificació AMS::62 Statistics::62H Multivariate analysis
dc.subject	Classificació AMS::62 Statistics::62D05 Sampling theory, sample surveys
dc.title	Combined treatment with environmental enrichment and (-)-epigallocatechin-3-gallate ameliorates learning deficits and hippocampal alterations in a mouse model of Down Syndrome
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	info:eu-repo/semantics/article
dc.description.abstract	Intellectual disability in Down syndrome (DS) is accompanied by altered neuro-architecture, deficient synaptic plasticity, and excitation-inhibition imbalance in critical brain regions for learning and memory. Recently, we have demonstrated beneficial effects of a combined treatment with green tea extract containing (-)-epigallocatechin-3-gallate (EGCG) and cognitive stimulation in young adult DS individuals. Although we could reproduce the cognitive-enhancing effects in mouse models, the underlying mechanisms of these beneficial effects are unknown. Here, we explored the effects of a combined therapy with environmental enrichment (EE) and EGCG in the Ts65Dn mouse model of DS at young age. Our results show that combined EE-EGCG treatment improved corticohippocampal-dependent learning and memory. Cognitive improvements were accompanied by a rescue of cornu ammonis 1 (CA1) dendritic spine density and a normalization of the proportion of excitatory and inhibitory synaptic markers in CA1 and dentate gyrus.
dc.description.abstract	Peer Reviewed

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