Title:
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Stereoselective syntheses of the antihistaminic drug olopatadine and its E-isomer
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Author:
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Bosch Cartes, Joan; Bachs, Jordi; Gómez, Antonia M.; Griera Farres, Rosa; Écija, Marta; Amat Tusón, Mercedes
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Other authors:
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Universitat de Barcelona |
Abstract:
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Practical stereoselective synthetic routes to the antihistaminic drug olopatadine and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to generate the ylide. |
Subject(s):
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-Antihistamínics -Estructura molecular -Síntesi orgànica -Antihistamines -Molecular structure -Organic synthesis |
Rights:
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(c) American Chemical Society , 2012
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Document type:
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Article Article - Accepted version |
Published by:
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American Chemical Society
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