dc.contributor |
Universitat Politècnica de Catalunya. Institut d'Investigació Tèxtil i Cooperació Industrial de Terrassa |
dc.contributor |
Universitat Politècnica de Catalunya. TECTEX - Grup de Recerca en Tecnologia Tèxtil |
dc.contributor.author |
Monterrubio, Carles |
dc.contributor.author |
Pascual Pasto, Guillem |
dc.contributor.author |
Cano Casas, Francesc |
dc.contributor.author |
Vilà Ubach, Mònica |
dc.contributor.author |
Manzanares Quintela, Alejandro |
dc.contributor.author |
Schaiqueviche, Paula |
dc.contributor.author |
Tornero García, José Antonio |
dc.contributor.author |
Sosnik, alejandro |
dc.contributor.author |
Mora Graupera, Jaume |
dc.contributor.author |
Montero Carcaboso, Ángel |
dc.date |
2015-12-02 |
dc.identifier.citation |
Monterrubio, C., Pascual, G., Cano, F., Vilà, M., Manzanares, A., Schaiqueviche, P., Tornero, J., Sosnik, A., Mora, J., Montero, Á. SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery. "Biomaterials", 02 Desembre 2015, vol. 79, p. 69-78. |
dc.identifier.citation |
0142-9612 |
dc.identifier.citation |
10.1016/j.biomaterials.2015.11.055 |
dc.identifier.uri |
http://hdl.handle.net/2117/81791 |
dc.language.iso |
eng |
dc.relation |
http://www.sciencedirect.com/science/article/pii/S0142961215009655 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Àrees temàtiques de la UPC::Enginyeria tèxtil::Teixits::Teixits mèdics |
dc.subject |
Àrees temàtiques de la UPC::Ciències de la salut::Medicina |
dc.subject |
Nanofibers |
dc.subject |
Chemotherapy |
dc.subject |
Tumors in children--Chemotherapy |
dc.subject |
Pharmacokinetics |
dc.subject |
Microdialysis--methods |
dc.subject |
Local chemotherapy delivery |
dc.subject |
SN-38 |
dc.subject |
Poly(lactic acid) electrospun nanofibers |
dc.subject |
Pediatric solid tumor |
dc.subject |
Pharmacokinetics |
dc.subject |
Microdialysis |
dc.subject |
Nanofibres |
dc.subject |
Quimioteràpia |
dc.subject |
Farmacocinètica |
dc.subject |
Tumors -- Tractament |
dc.title |
SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery |
dc.type |
info:eu-repo/semantics/submittedVersion |
dc.type |
info:eu-repo/semantics/article |
dc.description.abstract |
In addition to surgery, local tumor control in pediatric oncology requires new treatments as an alternative to radiotherapy. SN-38 is an anticancer drug with proved activity against several pediatric solid tumors including neuroblastoma, rhabdomyosarcoma and Ewing sarcoma. Taking advantage of the extremely low aqueous solubility of SN-38, we have developed a novel drug delivery system (DDS) consisting of matrices made of poly(lactic acid) electrospun polymer nanofibers loaded with SN-38 microcrystals for local release in difficult-to-treat pediatric solid tumors. To model the clinical scenario, we conducted extensive preclinical experiments to characterize the biodistribution of the released SN-38 using microdialysis sampling in vivo. We observed that the drug achieves high concentrations in the virtual space of the surgical bed and penetrates a maximum distance of 2 mm within the tumor bulk. Subsequently, we developed a model of subtotal tumor resection in clinically relevant pediatric patient-derived xenografts and used such models to provide evidence of the activity of the SN-38 DDS to inhibit tumor regrowth. We propose that this novel DDS could represent a potential future strategy to avoid harmful radiation therapy as a primary tumor control together with surgery |
dc.description.abstract |
In addition to surgery, local tumor control in pediatric oncology requires new treatments as an alternative to radiotherapy. SN-38 is an anticancer drug with proved activity against several pediatric solid tumors including neuroblastoma, rhabdomyosarcoma and Ewing sarcoma. Taking advantage of the extremely low aqueous solubility of SN-38, we have developed a novel drug delivery system (DDS) consisting of matrices made of poly(lactic acid) electrospun polymer nanofibers loaded with SN-38 microcrystals for local release in difficult-to-treat pediatric solid tumors. To model the clinical scenario, we conducted extensive preclinical experiments to characterize the biodistribution of the released SN-38 using microdialysis sampling in vivo. We observed that the drug achieves high concentrations in the virtual space of the surgical bed and penetrates a maximum distance of 2 mm within the tumor bulk. Subsequently, we developed a model of subtotal tumor resection in clinically relevant pediatric patient-derived xenografts and used such models to provide evidence of the activity of the SN-38 DDS to inhibit tumor regrowth. We propose that this novel DDS could represent a potential future strategy to avoid harmful radiation therapy as a primary tumor control together with surgery |