Abstract—Industrial process monitoring and modelling represents a critical step in order to achieve the paradigm of Zero Defect Manufacturing. The aim of this paper is to introduce the Neo-Fuzzy Neuron method to be applied in industrial time series modelling. Its open structure and input independency provides fast learning and convergence capabilities, while assuring a proper accuracy and generalization in the modelled output. First, the auxiliary signals in the database are analyzed in order to find correlations with the target signal. Second, the Neo-Fuzzy Neuron is configured and trained according by means of the auxiliary signal, past instants and dynamics information of the target signal. The proposed method is validated by means of real data from a Spanish copper rod industrial plant, in which a critical signal regarding copper refrigeration process is modelled. The obtained results indicate the suitability of the Neo-Fuzzy Neuron method for industrial process modelling.