Título:
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Adaptation of targeted nanocarriers to changing requirements in
antimalarial drug delivery
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Autor/a:
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Marques, Joana; Valle Delgado, Juan José; Urbán, Patricia; Baró, Elisabet; Prohens López, Rafael; Mayor Aparicio, Alfredo Gabriel; Cisteró, Pau; Delves, Michael; Sinden, Robert E.; Grandfils, Christian; Paz, José L. de; García Salcedo, José A.; Fernàndez Busquets, Xavier
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Abstract:
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The adaptation of existing antimalarial nanocarriers to new
Plasmodium stages, drugs, targeting molecules, or encapsulating
structures is a strategy that can provide new
nanotechnology-based, cost-efficient therapies against malaria.
We have explored the modification of different liposome
prototypes that had been developed in our group for the targeted
delivery of antimalarial drugs to Plasmodium-infected red blood
cells (pRBCs). These new models include: (i)
immunoliposome-mediated release of new lipid-based
antimalarials; (ii) liposomes targeted to pRBCs with covalently
linked heparin to reduce anticoagulation risks; (iii) adaptation
of heparin to pRBC targeting of chitosan nanoparticles; (iv) use
of heparin for the targeting of Plasmodium stages in the
mosquito vector; and (v) use of the non-anticoagulant
glycosaminoglycan chondroitin 4-sulfate as a heparin surrogate
for pRBC targeting. The results presented indicate that the
tuning of existing nanovessels to new malaria-related targets is
a valid low-cost alternative to the de novo development of
targeted nanosystems. |
Materia(s):
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-Nanomedicina -Malària -Nanomedicine -Malaria |
Derechos:
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cc by (c) Marques et al., 2016
http://creativecommons.org/licenses/by/3.0/es/ |
Tipo de documento:
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Artículo Artículo - Versión aceptada |
Editor:
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Elsevier
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Compartir:
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