Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy

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RECERCAT Home > Universitat de Barcelona > Institut d'lnvestigaciò Biomèdica de Bellvitge (IDIBELL) > Articles publicats en revistes (Institut d'lnvestigaciò Biomèdica de Bellvitge (IDIBELL)) > View document

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Title:	Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy
Author:	Sierra, Josep M.; Camoez, Mariana; Tubau, Fe; Gasch, Oriol; Pujol Rojo, Miquel; Martin, Rogelio; Domínguez Luzón, Ma. Ángeles (María Ángeles)
Abstract:	Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid resistance among MRSA clinical isolates in our area. A very low prevalence of cfr mediated linezolid resistance was found: only one bacteremic isolate out of 2 215 screened isolates. The only linezolid resistant isolate arose in a patient, previously colonized by MRSA, following linezolid therapy. Despite the low rate of resistance in our area, ongoing surveillance is advisable to avoid the spread of linezolid resistance.
Subject(s):	-Staphylococcus aureus -Unitats de cures intensives -Infeccions respiratòries -Staphylococcus aureus -Intensive care units -Respiratory infections
Rights:	cc-by (c) Sierra, J.M. et al., 2013 http://creativecommons.org/licenses/by/3.0/es
Document type:	Article Article - Published version
Published by:	Public Library of Science (PLoS)
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