Pauson-Khand Adducts of N-Boc-propargylamine: A New Approach to 4,5-Disubstituted Cyclopentenones

Consultar RECERCAT

Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/50467

Título:	Pauson-Khand Adducts of N-Boc-propargylamine: A New Approach to 4,5-Disubstituted Cyclopentenones
Autor/a:	Aiguabella Font, Núria; Pesquer, Albert; Verdaguer i Espaulella, Xavier; Riera i Escalé, Antoni
Otros autores:	Universitat de Barcelona
Abstract:	A new approach to the synthesis of 4,5-disubstituted cyclopentenones is described. The strategy is based on the Pauson-Khand (PK) reaction of norbornadiene and N-Boc-propargylamine as alkyne with a masked leaving group, which can be eliminated at will. This approach to the synthesis of 4,5-disubstituted cyclopentenones overcomes the problem of using the alkylation to introduce the alpha-side-chain. As an example, prostane 13-epi-12-oxo-phytodienoic acid (13-epi-12-oxo-PDA) methyl ester was synthesized.
Materia(s):	-Ciclització (Química) -Química biorgànica -Compostos orgànics -Síntesi orgànica -Hormones -Efecte de l'estrès sobre les plantes -Estrès (Psicologia) -Prostaglandines -Biomolècules -Ring formation (Chemistry) -Bioorganic chemistry -Organic compounds -Organic synthesis -Hormones -Effect of stress on plants -Stress (Psychology) -Prostaglandins -Biomolecules
Derechos:	(c) American Chemical Society , 2013
Tipo de documento:	Artículo Artículo - Versión aceptada
Editor:	American Chemical Society
Compartir:

Aiguabella Font, Núria; Arce, Elsa M.; Pozo, Carlos del; Verdaguer i Espaulella, Xavier; Riera i Escalé, Antoni

Salomó, Ernest; Orgué Gassol, Sílvia; Riera i Escalé, Antoni; Verdaguer i Espaulella, Xavier

Salomó, Ernest; Prades, Amparo; Riera i Escalé, Antoni; Verdaguer i Espaulella, Xavier

Orgué Gassol, Sílvia; Flores-Gaspar, Areli; Biosca, Maria; Pàmies, Oscar; Diéguez, Montserrat; Riera i Escalé, Antoni; Verdaguer i Espaulella, Xavier

Cabré, Albert; Verdaguer i Espaulella, Xavier; Riera i Escalé, Antoni

Coordinación

Patrocinio