Solid-phase synthesis and DNA binding studies of dichloroplatinum(II) conjugates of dicarba analogues of octreotide as a new anticancer drugs

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dc.contributor	Universitat de Barcelona
dc.contributor.author	Barragán, Flavia
dc.contributor.author	Moreno Martínez, Virtudes
dc.contributor.author	Marchán Sancho, Vicente
dc.date	2013-06-14T07:50:44Z
dc.date	2013-06-14T07:50:44Z
dc.date	2009
dc.date	2013-06-14T07:50:44Z
dc.identifier.citation	1359-7345
dc.identifier.citation	568522
dc.identifier.uri	http://hdl.handle.net/2445/44244
dc.format	3 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Royal Society of Chemistry
dc.relation	Versió postprint del document publicat a: http://dx.doi.org/10.1039/B909698A
dc.relation	Chemical Communications, 2009, p. 4705-4707
dc.relation	http://dx.doi.org/10.1039/B909698A
dc.rights	(c) Barragán, Flavia et al., 2009
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	ADN
dc.subject	Química bioinorgànica
dc.subject	Quimioteràpia del càncer
dc.subject	Cèl·lules canceroses
dc.subject	Toxicitat dels medicaments
dc.subject	DNA
dc.subject	Bioinorganic chemistry
dc.subject	Cancer chemotherapy
dc.subject	Cancer cells
dc.subject	Drug toxicity
dc.title	Solid-phase synthesis and DNA binding studies of dichloroplatinum(II) conjugates of dicarba analogues of octreotide as a new anticancer drugs
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion
dc.description.abstract	The first dichloroplatinum(II) conjugates of dicarba analogues of octreotide , which is expected to act as a"tumour-targeting device", have been efficiently synthesized following a stepwise solid-phase approach; these compounds emulate the mechanism of cisplatin since they form a 1,2-intrastrand cross-link with two consecutive guanines of an oligonucleotide.

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