Differential inhibition of the TGF-b signaling pathway in HCC cells using the small molecule inhibitor LY2157299 and the D10 monoclonal antibody against TGF-β receptor Type II

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RECERCAT Home > Universitat de Barcelona > Ciències Fisiològiques > Articles publicats en revistes (Ciències Fisiològiques) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/97493

dc.contributor	Universitat de Barcelona
dc.contributor.author	Dituri, Francesco
dc.contributor.author	Mazzocca, Antonio
dc.contributor.author	Peidrò, Fernando Juan
dc.contributor.author	Papappicco, Patrizia
dc.contributor.author	Fabregat Romero, Isabel
dc.contributor.author	De Santis, Flavia
dc.contributor.author	Paradiso, Angelo
dc.contributor.author	Sabbà, Carlo
dc.contributor.author	Giannelli, Gianluigi
dc.date	2016-04-15T13:57:06Z
dc.date	2016-04-15T13:57:06Z
dc.date	2013
dc.date	2016-04-15T13:57:12Z
dc.identifier.citation	1932-6203
dc.identifier.citation	639728
dc.identifier.uri	http://hdl.handle.net/2445/97493
dc.format	15 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Public Library of Science (PLoS)
dc.relation	Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0067109
dc.relation	PLoS One, 2013, vol. 8, num. 6, p. e67109
dc.relation	http://dx.doi.org/10.1371/journal.pone.0067109
dc.rights	cc-by (c) Dituri, Francesco et al., 2013
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.subject	Anticossos monoclonals
dc.subject	Fosforilació
dc.subject	Càncer de fetge
dc.subject	Factors de creixement
dc.subject	Monoclonal antibodies
dc.subject	Phosphorylation
dc.subject	Liver cancer
dc.subject	Growth factors
dc.title	Differential inhibition of the TGF-b signaling pathway in HCC cells using the small molecule inhibitor LY2157299 and the D10 monoclonal antibody against TGF-β receptor Type II
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	We investigated blocking the TGF-b signaling pathway in HCC using two small molecule inhibitors (LY2157299, LY2109761) and a neutralizing humanized antibody (D10) against TGF-bRII. LY2157299 and LY2109761 inhibited HCC cell migration on Laminin-5, Fibronectin, Vitronectin, Fibrinogen and Collagen-I and de novo phosphorylation of pSMAD2. LY2157299 inhibited HCC migration and cell growth independently of the expression levels of TGF-bRII. In contrast to LY2157299, D10 showed a reduction in pSMAD2 only after a short exposure. This study supports the use of LY2157299 in clinical trials, and presents new insights into TGF-b receptor cycling in cancer cells.

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