dc.contributor.author |
Couch, Robert B. |
dc.contributor.author |
Bayas Rodríguez, José María |
dc.contributor.author |
Caso, Covadonga |
dc.contributor.author |
Mbawuike, Innocent Nnadi |
dc.contributor.author |
Núñez López, Concepción |
dc.contributor.author |
Claeys, Carine |
dc.contributor.author |
El Idrissi, Mohamed |
dc.contributor.author |
Herve, Caroline |
dc.contributor.author |
Laupeze, Beatrice |
dc.contributor.author |
Oostvogels, Lidia |
dc.contributor.author |
Moris, Philippe |
dc.date |
2015-12-14T13:19:59Z |
dc.date |
2015-12-14T13:19:59Z |
dc.date |
2014-07-30 |
dc.date |
2015-12-04T15:27:49Z |
dc.identifier.citation |
1471-2334 |
dc.identifier.uri |
http://hdl.handle.net/2445/68435 |
dc.format |
14 p. |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
BioMed Central |
dc.relation |
Reproducció del document publicat a: http://dx.doi.org/10.1186/1471-2334-14-425 |
dc.relation |
BMC Infectious Diseases, 2014, num. 14, p. 425 |
dc.relation |
http://dx.doi.org/10.1186/1471-2334-14-425 |
dc.rights |
cc by (c) Couch et al., 2014 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.rights |
http://creativecommons.org/licenses/by/3.0/es/ |
dc.subject |
Grip |
dc.subject |
Vacunació |
dc.subject |
Persones grans |
dc.subject |
Assaigs clínics |
dc.subject |
Influenza |
dc.subject |
Vaccination |
dc.subject |
Older people |
dc.subject |
Clinical trials |
dc.title |
Superior antigen-specific CD4+ T-cell response with AS03-adjuvantation of a trivalent influenza vaccine in a randomised trial of adults aged 65 and older |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.description.abstract |
BACKGROUND: The effectiveness of trivalent influenza vaccines may be reduced in older versus younger adults because of age-related immunosenescence. The use of an adjuvant in such a vaccine is one strategy that may combat immunosenescence, potentially by bolstering T-cell mediated responses.
METHODS: This observer-blind study, conducted in the United States (US) and Spain during the 2008-2009 influenza season, evaluated the effect of Adjuvant System AS03 on specific T-cell responses to a seasonal trivalent influenza vaccine (TIV) in >/=65 year-old adults.Medically-stable adults aged >/=65 years were randomly allocated to receive a single dose of AS03-adjuvanted TIV (TIV/AS03) or TIV. Healthy adults aged 18-40 years received only TIV. Blood samples were collected on Day 0, Day 21, Day 42 and Day 180. Influenza-specific CD4+ T cells, defined by the induction of the immune markers CD40L, IL-2, IFN-gamma, or TNF-alpha, were measured in ex vivo cultures of antigen-stimulated peripheral blood mononuclear cells.
RESULTS: A total of 192 adults were vaccinated: sixty nine and seventy three >/=65 year olds received TIV/AS03 and TIV, respectively; and fifty 18 - 40 year olds received TIV. In the >/=65 year-old group on Day 21, the frequency of CD4+ T cells specific to the three vaccine strains was superior in the TIV/AS03 recipients to the frequency in TIV (p < 0.001). On Days 42 and 180, the adjusted-geometric mean specific CD4+ T-cell frequencies were also higher in the TIV/AS03 recipients than in the TIV recipients (p < 0.001). Furthermore, the adjusted-geometric mean specific CD4+ T-cell frequencies were higher in the >/=65 year-old recipients of TIV/AS03 than in the 18 - 40 year old recipients of TIV on Days 21 (p = 0.006) and 42 (p = 0.011). CONCLUSION: This positive effect of AS03 Adjuvant System on the CD4+ T-cell response to influenza vaccine strains in older adults could confer benefit in protection against clinical influenza disease in this population.
TRIAL REGISTRATION: (Clinicaltrials.gov.). NCT00765076. |