The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression

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RECERCAT Home > Universitat de Barcelona > Institut d'lnvestigaciò Biomèdica de Bellvitge (IDIBELL) > Articles publicats en revistes (Institut d'lnvestigaciò Biomèdica de Bellvitge (IDIBELL)) > View document

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dc.contributor.author	Saurí Duran, Jaume
dc.contributor.author	Millán, D.
dc.contributor.author	Suñé i Negre, Josep M. (Josep Maria)
dc.contributor.author	Pérez Lozano, Pilar
dc.contributor.author	Sarrate, R. (Rocío)
dc.contributor.author	Fábregas, A. (Anna)
dc.contributor.author	Carrillo Sánchez, Carolina
dc.contributor.author	Miñarro Carmona, Montserrat
dc.contributor.author	Ticó Grau, Josep R.
dc.contributor.author	García Montoya, Encarna
dc.date	2014-04-08T09:05:35Z
dc.date	2014-04-08T09:05:35Z
dc.date	2014-01-30
dc.date	2014-04-08T09:05:36Z
dc.identifier.citation	0378-5173
dc.identifier.citation	630651
dc.identifier.uri	http://hdl.handle.net/2445/53332
dc.format	8 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Elsevier B.V.
dc.relation	Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.ijpharm.2013.11.029
dc.relation	International Journal of Pharmaceutics, 2014, vol. 461, num. 1-2, p. 38-45
dc.relation	http://dx.doi.org/10.1016/j.ijpharm.2013.11.029
dc.rights	(c) Elsevier B.V., 2014
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Comprimits (Medicina)
dc.subject	Medicació oral
dc.subject	Excipients
dc.subject	Control de qualitat
dc.subject	Medicaments d'alliberament retardat
dc.subject	Tecnologia farmacèutica
dc.subject	Pólvores (Farmàcia)
dc.subject	Tablets (Medicine)
dc.subject	Oral medication
dc.subject	Excipients
dc.subject	Quality control
dc.subject	Delayed-action drugs
dc.subject	Pharmaceutical technology
dc.subject	Powders (Pharmacy)
dc.title	The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion
dc.description.abstract	The SeDeM Diagram Expert System has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril Direct Compression SR Matrix Tablets. The application of the Sedem Diagram Expert System enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. The methodology is based on the implementation of ICH Q8, establishing the design space of the formula with the use of experiment design, using the parameters of the SeDeM Diagram Expert System as system responses.

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