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Title:
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Design considerations for a CMOS Lab-on-Chip microheater array to facilitate the in vitro thermal stimulation of neurons
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Author:
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Reverter Cubarsí, Ferran; Prodromakis, Themis; Liu, Yan; Georgiou, Pantelis; Nikolic, Konstantin; Constandinou, Tim
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Other authors:
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica; Universitat Politècnica de Catalunya. e-CAT - Circuits i Transductors Electrònics |
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Abstract:
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This paper identifies and addresses key design considerations and trade-offs in the implementation of a CMOS high-resolution microheater array for Lab-on-Chip (LOC) applications. Specifically, this is investigated in the context of facilitating the in vitro thermal stimulation of single neurons. The paper analyses the electro-thermal response (by means of COMSOL simulations) and reliability issues (such as melting and electromigration) of different microheater designs. The analysis shows that a small-area heater is more efficient in terms of power, but it has more reliability problems essentially due to electromigration effects. For the proposed heater designs, the expected lifetime is a few days (in continuous operation) in the worst scenario, which is still generally acceptable for LOC applications. |
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Abstract:
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Peer Reviewed |
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Subject(s):
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-Àrees temàtiques de la UPC::Física::Electromagnetisme
-Àrees temàtiques de la UPC::Enginyeria electrònica::Electrònica de potència
-Electromagnetism
-Electronic circuits
-lab-on-chip
-heater
-neurons
-thermal stimulation
-Circuits electronics |
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Rights:
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Document type:
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Article - Published version
Conference Object |
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Published by:
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Institute of Electrical and Electronics Engineers (IEEE)
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