Energy refurbishment of the existing housing stocks main goals are: to decrease fossil fuels consumption, to reduce the CO2 emissions, and to improve indoor environment quality. The main objective of the presented investigation was to evaluate the integrated design strategies applied in refurbishment of the prefabricated residential housing, in order to achieve energy savings accompanied with reduction of CO2 emissions and improvement of households’ health and comfort. Conducted study led to the preliminary design of energy refurbishment of the existing building, and its conversion to energy efficient building approaching Zero Energy and Zero CO2 emission status, covering minimized loads and energy needs exclusively by renewable energy sources. Building’s dynamic behavior and energy efficiency have been optimized implementing BPS. Refurbishment encompassed comprehensive optimization of building’s envelope structure, natural and mixed ventilation, and HVAC system. The implementation of a series of EEI (energy efficiency improvement) measures resulted in significant reduction of buildings energy loads. Locally available solar (BIPV) and groundwater via heat pump operation, as renewable energy sources (RES) have been selected to cover as more as possible of the building’s residual energy demand. Presented methodology and results of the performed analysis offer an opportunity to extend their application to other building blocks and neighbo rhoods, exploring refurbishment potential results if applied on greater urban scales within the whole city.